Primary Response Genes Induced by Growth Factors and Tumor Promoters

Primary Response Genes Induced by Growth Factors and Tumor Promoters 281 0066-4 1 54/91/0701 -0281$02 . 00 HERSCHMAN SUMMARY AND PERSPECTIVES All nucleated eukaryotic cells exhibit ligand-induced, transcription-dependent changes in phenotype. Even the single-celled yeasts respond to polypeptide mating factors by alterations in cellular proliferation and mating capability that are dependent on receptor-mediated transcriptional activation . In multi­ cellular organisms , individual cells constantly respond to a complex environ­ ment in which gene expression and 'consequent cellular phenotype are medi­ ated by ligands such as growth factors , peptide hormones, neurotransmitters, antigens , morphogens, and other hydrophilic agents that bind to cell-surface, transmembrane receptors . Researchers studying area� as seemingly diverse as mitogenesis, endocrinology, immunology, neurobiology, and developmental biology are all confronted with a similar set of questions: How is the informa­ tion that a ligand-receptor interaction has occurred at the cell surface transmit­ ted across the membrane? What are the intracellular mechanisms that relay, from the membrane to the nucleus, the information that a cell-surface, ligand-receptor interaction has occurred? What genes are influenced as a result of this new information, and how is their expression selectively mod­ ulated? What are the roles of these new gene products, expressed in response to ligand-receptor interaction, in effecting the subsequent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Primary Response Genes Induced by Growth Factors and Tumor Promoters

Annual Review of Biochemistry, Volume 60 (1) – Jul 1, 1991

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Publisher
Annual Reviews
Copyright
Copyright 1991 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
D.O.I.
10.1146/annurev.bi.60.070191.001433
Publisher site
See Article on Publisher Site

Abstract

281 0066-4 1 54/91/0701 -0281$02 . 00 HERSCHMAN SUMMARY AND PERSPECTIVES All nucleated eukaryotic cells exhibit ligand-induced, transcription-dependent changes in phenotype. Even the single-celled yeasts respond to polypeptide mating factors by alterations in cellular proliferation and mating capability that are dependent on receptor-mediated transcriptional activation . In multi­ cellular organisms , individual cells constantly respond to a complex environ­ ment in which gene expression and 'consequent cellular phenotype are medi­ ated by ligands such as growth factors , peptide hormones, neurotransmitters, antigens , morphogens, and other hydrophilic agents that bind to cell-surface, transmembrane receptors . Researchers studying area� as seemingly diverse as mitogenesis, endocrinology, immunology, neurobiology, and developmental biology are all confronted with a similar set of questions: How is the informa­ tion that a ligand-receptor interaction has occurred at the cell surface transmit­ ted across the membrane? What are the intracellular mechanisms that relay, from the membrane to the nucleus, the information that a cell-surface, ligand-receptor interaction has occurred? What genes are influenced as a result of this new information, and how is their expression selectively mod­ ulated? What are the roles of these new gene products, expressed in response to ligand-receptor interaction, in effecting the subsequent

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1991

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