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Physiology of Sympathetic Denervation

Physiology of Sympathetic Denervation into the laboratory and clinic of drugs which depress sympathetic activity but which also produce side effects, altering the basic response to sympa­ thetic denervation. For example, ganglionic blocking agents such as hexa­ methonium chloride block parasympathetic as well as sympathetic ganglia. The resulting physiological response, especially with respect to the cardiac vagus, is not typical of sympathetic denervation alone. Hexamethonium has also been reported as having a positive inotropic effect (2), which, together with its effect in experimental traumatic shock (3), suggests the possibility that hexamethonium has direct cellular actions in addition to its action as a ganglionic blocking agent. The possibility of side actions becomes greater with recently introduced drugs such as guanethidine, bretylium, and phe­ noxybenzamine hydrochloride. Such drugs alter normal sympathetic nervous system activity, but the possibility of their having other less conspicuous but physiologically important actions has not yet been adequately investi­ gated. Because the physiological effects of "pure" sympathetic denervation uncomplicated by surgery or the administration of drugs with potential or proven side actions has not recently been reviewed, the present article will limit itself to this aspect of the problem. Emphasis will be placed, insofar as possible, on the effects of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Physiology of Sympathetic Denervation

Greene, N M
Annual Review of Medicine , Volume 13 (1) – Feb 1, 1962
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Publisher
Annual Reviews
Copyright
Copyright 1962 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.13.020162.000511
pmid
13901533
Publisher site
See Article on Publisher Site

Abstract

into the laboratory and clinic of drugs which depress sympathetic activity but which also produce side effects, altering the basic response to sympa­ thetic denervation. For example, ganglionic blocking agents such as hexa­ methonium chloride block parasympathetic as well as sympathetic ganglia. The resulting physiological response, especially with respect to the cardiac vagus, is not typical of sympathetic denervation alone. Hexamethonium has also been reported as having a positive inotropic effect (2), which, together with its effect in experimental traumatic shock (3), suggests the possibility that hexamethonium has direct cellular actions in addition to its action as a ganglionic blocking agent. The possibility of side actions becomes greater with recently introduced drugs such as guanethidine, bretylium, and phe­ noxybenzamine hydrochloride. Such drugs alter normal sympathetic nervous system activity, but the possibility of their having other less conspicuous but physiologically important actions has not yet been adequately investi­ gated. Because the physiological effects of "pure" sympathetic denervation uncomplicated by surgery or the administration of drugs with potential or proven side actions has not recently been reviewed, the present article will limit itself to this aspect of the problem. Emphasis will be placed, insofar as possible, on the effects of

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1962

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