Fibronectin is a major protein of blood and tissues. It has been intensively studied because of its many interactions with cells and other macromoleÂ cules. Fibronectin is a principal component of the extracellular matrix, and its most important function seems to be in tissue remodelling during embryogenesis and wound healing. It may influence a number of other physiological processes, including phagocytosis. The concentration of plasma fibronectin and the distribution of tissue fibronectin are altered in disease states, although diseases specifically caused by quantitative or qualitative abnormalities of fibronectin have not been identified. Fibronectin is a Major Protein of Blood and Tissues Fibronectin is a glycoprotein found in the extracellular space of most tissues. It occurs in both soluble and insoluble forms. The concentration of fibronectin in plasma is approximately 300 flg/ml (1, 2). Soluble fibronectin is also found in amniotic fluid (3), seminal fluid (4, 5), joint fluid (6-8), and cerebrospinal fluid (5, 9). Fibronectin is synthesized and secreted in large amounts by a number of cell types in culture (see 10 and 11). Insoluble fibronectin is a component of fibrillar extracellular structures and basement membranes of all tissues with the possible exception of the nervous system (12).
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1984
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera