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Pharmacological Aspects of Metabolic Processes in the Pulmonary Microcirculation

Pharmacological Aspects of Metabolic Processes in the Pulmonary Microcirculation Lung pharmacology is concerned with both therapeutic and toxic effects of drugs on lung cells and cellular processes. Increasingly in the last several years, those interested in this field have also focused their attention on actions of lung on drugs and toxins reaching it via the air space or blood-the pharmacokinetic (metabolic or nonrespiratory) function of lung (1,2). These occur in many cells of the lung; however, particularly intimate contact of the delicate alveolar­ capillary unit with both the external environment and blood makes this site a frequent focus of injury due to environmental or vascular insults, such as hyperoxia, xenobiotic toxicity, septicemia, and adult respiratory distress in man (1, 2, 2a). This, coupled with the intense metabolic activity known to occur in cells of the alveolar-capillary membrane,has generated much effort to understand mechanisms and the significance of lung metabolic functions. In carrying out these functions, the lung acts as a highly efficient "biochemi­ cal filter" for central venous blood. This reflects primarily two actions. First, the pUlmonary circulation is interposed between the right and the left heart,and therefore all circulating blood passes through the lungs about once per minute. Secondly, within the lung, blood interacts with the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Pharmacological Aspects of Metabolic Processes in the Pulmonary Microcirculation

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.001151
pmid
3013078
Publisher site
See Article on Publisher Site

Abstract

Lung pharmacology is concerned with both therapeutic and toxic effects of drugs on lung cells and cellular processes. Increasingly in the last several years, those interested in this field have also focused their attention on actions of lung on drugs and toxins reaching it via the air space or blood-the pharmacokinetic (metabolic or nonrespiratory) function of lung (1,2). These occur in many cells of the lung; however, particularly intimate contact of the delicate alveolar­ capillary unit with both the external environment and blood makes this site a frequent focus of injury due to environmental or vascular insults, such as hyperoxia, xenobiotic toxicity, septicemia, and adult respiratory distress in man (1, 2, 2a). This, coupled with the intense metabolic activity known to occur in cells of the alveolar-capillary membrane,has generated much effort to understand mechanisms and the significance of lung metabolic functions. In carrying out these functions, the lung acts as a highly efficient "biochemi­ cal filter" for central venous blood. This reflects primarily two actions. First, the pUlmonary circulation is interposed between the right and the left heart,and therefore all circulating blood passes through the lungs about once per minute. Secondly, within the lung, blood interacts with the

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

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