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Osteoporosis

Osteoporosis By MARSHALL R. URIST, M.D.2 Division of Orthopedics, Department of Surgery, University of California Medical Center, Los Angeles, California The literature on osteoporosis was analyzed from the endocrinologic aspect by Reifenstein in 1957 (1) , and from the aspect of nutrition and calcium deficiency by Nordin (2) in 1960. The subject has occupied an important position during the past five years, in editorials (3, 4), sym­ posia (5, 6), and in new books on calcium and bone metabolism (7 to 12). This chapter will review articles dealing with pathological physiology and clinical experiments that assess the value of various treatments. Space is available here for 100 titles but more than twice that number has ap­ peared in the world literature during the past five years; these exclude reports on local and regional forms of osteoporosis. Systemic osteoporosis is generally recognized by inadequate bone mass per unit volume of skeleton owing to generalized loss of spongiosa and inner layers of cortex. Without any change in the external dimensions of the bones, fibrous tissue, fat, and marrow replace the hard tissue and eventually pathological frac­ tures appear in vertebra, ribs, and femora. EXPERIMENTAL OSTEOPOROSIS Osteoporosis develops spontaneously in wild animals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Osteoporosis

Urist, M R
Annual Review of Medicine , Volume 13 (1) – Feb 1, 1962
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Publisher
Annual Reviews
Copyright
Copyright 1962 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.13.020162.001421
pmid
13923923
Publisher site
See Article on Publisher Site

Abstract

By MARSHALL R. URIST, M.D.2 Division of Orthopedics, Department of Surgery, University of California Medical Center, Los Angeles, California The literature on osteoporosis was analyzed from the endocrinologic aspect by Reifenstein in 1957 (1) , and from the aspect of nutrition and calcium deficiency by Nordin (2) in 1960. The subject has occupied an important position during the past five years, in editorials (3, 4), sym­ posia (5, 6), and in new books on calcium and bone metabolism (7 to 12). This chapter will review articles dealing with pathological physiology and clinical experiments that assess the value of various treatments. Space is available here for 100 titles but more than twice that number has ap­ peared in the world literature during the past five years; these exclude reports on local and regional forms of osteoporosis. Systemic osteoporosis is generally recognized by inadequate bone mass per unit volume of skeleton owing to generalized loss of spongiosa and inner layers of cortex. Without any change in the external dimensions of the bones, fibrous tissue, fat, and marrow replace the hard tissue and eventually pathological frac­ tures appear in vertebra, ribs, and femora. EXPERIMENTAL OSTEOPOROSIS Osteoporosis develops spontaneously in wild animals

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1962

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