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Proenkephalin A (p121 meta pre -.... 8kO [}i o Proenkephalin 8 (Prodynorphin) .. -nE fI-nE Q-l � O---i leu-m [)------{}-i d Yn 32 � dyn-24 [}-i dyn B dyn A Q---i dyn A ( I-B) D� - 6KO OPIOID PEPTIDES the guinea-pig ileum and the vasa deferentia of the mouse, rat, and rabbit has led to the observation that, in addition to interacting with the J..L- and K-types of opioid receptors, the opioids can interact with �- (0) and E- receptors [(11); reviewed in (12)]. In this review an attempt is made to summarize the literature describing the various products of processing of the three opioid precursors and their selectivity for the different classes of opioid receptors. THE PROOPIOMELANOCORTIN (POMC) SYSTEM Processing Products The structure of bovinePOMC, together with its major processing products, is shown schematically in Figure 1 (13). Each of the peptides in the precursor molecule is bounded by pairs of basic amino acid residues, which represent the sites of proteolytic processing (14). The major source of POMC production is t he pituitary. Studies of b iosynt hesis have revealed that the processin g of POMC in the intermediate lobe of rats is different from that
Annual Review of Pharmacology and Toxicology – Annual Reviews
Published: Apr 1, 1986
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