Opioid Peptide Processing and Receptor Selectivity

Opioid Peptide Processing and Receptor Selectivity Proenkephalin A (p121 meta pre -.... 8kO [}i o Proenkephalin 8 (Prodynorphin) .. -nE fI-nE Q-l � O---i leu-m [)------{}-i d Yn 32 � dyn-24 [}-i dyn B dyn A Q---i dyn A ( I-B) D� - 6KO OPIOID PEPTIDES the guinea-pig ileum and the vasa deferentia of the mouse, rat, and rabbit has led to the observation that, in addition to interacting with the J..L- and K-types of opioid receptors, the opioids can interact with �- (0) and E- receptors [(11); reviewed in (12)]. In this review an attempt is made to summarize the literature describing the various products of processing of the three opioid precursors and their selectivity for the different classes of opioid receptors. THE PROOPIOMELANOCORTIN (POMC) SYSTEM Processing Products The structure of bovinePOMC, together with its major processing products, is shown schematically in Figure 1 (13). Each of the peptides in the precursor molecule is bounded by pairs of basic amino acid residues, which represent the sites of proteolytic processing (14). The major source of POMC production is t he pituitary. Studies of b iosynt hesis have revealed that the processin g of POMC in the intermediate lobe of rats is different from that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Opioid Peptide Processing and Receptor Selectivity

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.000423
Publisher site
See Article on Publisher Site

Abstract

Proenkephalin A (p121 meta pre -.... 8kO [}i o Proenkephalin 8 (Prodynorphin) .. -nE fI-nE Q-l � O---i leu-m [)------{}-i d Yn 32 � dyn-24 [}-i dyn B dyn A Q---i dyn A ( I-B) D� - 6KO OPIOID PEPTIDES the guinea-pig ileum and the vasa deferentia of the mouse, rat, and rabbit has led to the observation that, in addition to interacting with the J..L- and K-types of opioid receptors, the opioids can interact with �- (0) and E- receptors [(11); reviewed in (12)]. In this review an attempt is made to summarize the literature describing the various products of processing of the three opioid precursors and their selectivity for the different classes of opioid receptors. THE PROOPIOMELANOCORTIN (POMC) SYSTEM Processing Products The structure of bovinePOMC, together with its major processing products, is shown schematically in Figure 1 (13). Each of the peptides in the precursor molecule is bounded by pairs of basic amino acid residues, which represent the sites of proteolytic processing (14). The major source of POMC production is t he pituitary. Studies of b iosynt hesis have revealed that the processin g of POMC in the intermediate lobe of rats is different from that

Journal

Annual Review of Pharmacology and ToxicologyAnnual Reviews

Published: Apr 1, 1986

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