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During the past 15 years, a number of studies involving several different scientific disciplines have associated malnutrition imposed during a critical period of development and permanent changes in brain structure and func tion. The implications of the observations in a world in which hundreds of millions of children have been and are continuing to be nutritionally deprived in infancy are obvious. Not only are they to be handicapped, but the result ing handicap may well prevent them from extricating themselves from the conditions which breed malnutrition, and therefore their children are at risk of suffering the same handicap. Thus, poverty results in undernutrition which causes retarded brain growth and function which limits earning capabilities which lead again to undernutrition. This is the vicious cycle first pointed out by Cravioto (1). This association of undernutrition and faulty development has been made in complex human situations and thus has not allowed isolation of malnutri tion as the only significant variable. Malnutrition occurs in a milieu of low socioeconomic status, reduced education, poor sanitary conditions, and is further complicated by recurrent and severe infections. These children, then, are exposed during their early formative life to a variety of complex environ mental
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1972
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