Historical Perspective Although nitric oxide (NO)3 was known since the late 1970s to be among the ligands that activate soluble guanylyl cyclase and cause vascular smooth musÂ cle relaxation (4, 21, 44), it was not appreciated until more recently that NO is also an endogenous vasorelaxant. In 1986, Furchgott (33) and Ignarro (56) noted that NO and endothelium-derived relaxing factor (EDRF) (32, 34) comÂ parably relax vascular smooth muscle and are similarly quenched by hemoÂ globin and superoxide. They proposed that EDRF is NO (33, 56) or a labile compound releasing NO (56). A variety of biological and pharmacological 3Abbreviations used: NO, nitric oxide; EDRF. endothelium-derived relaxing factor; EPR. electron paramagnetic resonance; NMDA.N-methyl-Daspartate; NOS. nitric oxide synthase; eNOS. ecNOS. NOS-III, endothelial constitutive isoform of NOS-; nNOS, ncNOS. bNOS. NOS-I. neuronal (brain) constitutive isoform of NOS; iNOS, mNOS. macNOS. NOS-II. Ca2+ elevation-independent, inducible isoform of NOS; THB, tetrahydrobiopterin; NOH-ARG. N!l)-hydroxY-L-arginine; LÂ· SMTC. S-methyl-L-thiocitrulline; L-NMA. ï¿½-methyl-L-arginine; L-NNA. N!l)-nitro-L-arginine; CaM. calmodulin; LPS.lipopolysaccharide; NANC. non-adrenergic. non-cholinergic; ROS. reac- tive oxygen species; D-NMA. N!l)-methyl-o-arginine; o-NNA. ï¿½-nitro-D-arginine; L-NAME. N!l)-nitro-L-arginine methyl ester; L-NAA. ï¿½-amino-L-arginine; L-NIO. ï¿½-iminoethyl- L-omithine. 707 0066-4278/95/0315-0707$05.00 GRIFFITH & STUEHR studies confirmed this conclusion with respect to NO (55, 108, 109; reviews 54,
Annual Review of Physiology – Annual Reviews
Published: Mar 1, 1995
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