New Neuronal Growth Factors

New Neuronal Growth Factors The complexity and remarkable specificity found in the nervous system chal­ lenge the investigator to identify molecular mechanisms guiding neuronal development. Cell-cell interactions mediated by diffusible substances have frequently been suggested to play an important role. Studies on naturally occurring cell death in the nervous system provided early evidence for such interactions by demonstrating that neuronal survival beyond a critical period in development requires interaction between the neurons and the postsynaptic target tissue (for a review see Oppenheim 1981). The discovery of Nerve Growth Factor (NGF) raised the possibility that neuronal development, includ­ ing target-dependent neuronal survival, might be mediated by diffusible mole­ cules. NGF can be isolated as a 140,000 dalton protein complex ( 7S NGF) of heterologous subunits or as a 26,500 dalton component (beta-NGF) containing two identical polypeptide chains. Experiments in vivo indicate that NGF can reverse naturally occurring as well as experimentally induced cell death in sympathetic and sensory neurons; moreover, anti-NGF antibodies in vivo can block the development of the s ympatheti c nervous system (for reviews see Thoenen & Barde 1980, Hamburger et al 1981, Levi-Monta1cini 1982). That NGF might also influence the choice of targets contacted by neurons is suggested by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

New Neuronal Growth Factors

Annual Review of Neuroscience, Volume 7 (1) – Mar 1, 1984

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Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
D.O.I.
10.1146/annurev.ne.07.030184.001053
Publisher site
See Article on Publisher Site

Abstract

The complexity and remarkable specificity found in the nervous system chal­ lenge the investigator to identify molecular mechanisms guiding neuronal development. Cell-cell interactions mediated by diffusible substances have frequently been suggested to play an important role. Studies on naturally occurring cell death in the nervous system provided early evidence for such interactions by demonstrating that neuronal survival beyond a critical period in development requires interaction between the neurons and the postsynaptic target tissue (for a review see Oppenheim 1981). The discovery of Nerve Growth Factor (NGF) raised the possibility that neuronal development, includ­ ing target-dependent neuronal survival, might be mediated by diffusible mole­ cules. NGF can be isolated as a 140,000 dalton protein complex ( 7S NGF) of heterologous subunits or as a 26,500 dalton component (beta-NGF) containing two identical polypeptide chains. Experiments in vivo indicate that NGF can reverse naturally occurring as well as experimentally induced cell death in sympathetic and sensory neurons; moreover, anti-NGF antibodies in vivo can block the development of the s ympatheti c nervous system (for reviews see Thoenen & Barde 1980, Hamburger et al 1981, Levi-Monta1cini 1982). That NGF might also influence the choice of targets contacted by neurons is suggested by

Journal

Annual Review of NeuroscienceAnnual Reviews

Published: Mar 1, 1984

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