Neuroendocrine Pharmacology of Serotonergic (5-HT) Neurons

Neuroendocrine Pharmacology of Serotonergic (5-HT) Neurons Serotonergic neurons are believed to play a role in depression, anxiety, and aggression (for review see l ). There is evidence that serotonergic neurons send collaterals to limbic and neuroendocrine control areas in the brain (2-3). Consequently, hormones that are released by serotonergic neurons might serve as diagnostic tools to evaluate the serotonergic involvement in emotion­ al disorders. This review is a survey of the evidence for serotonergic regula­ tion of ACTH, {3-endorphin, prolactin, renin, oxytocin, vasopressin, growth hormone (GH), and luteinizing hormone (LH) secretion. The anatomy of the serotonergic pathways is discussed briefly , followed by a concise overview of the pharmacology of serotonergic neurotransmission. The evidence for a role of serotonergic neurons in the regulation of each individual hormone is divided into three sections: (a) the anatomical organization; (b) the physiolog­ ical function; and (c) the 5-HT receptor subtypes involved in the regulation of each hormone. 0362-1642/91/0415-0289$02.00 VAN DE KAR NEUROANATOMY OF BRAIN SEROTONERGIC NEURONS Serotonergic cell bodies, designated B1-B8 cell groups, are found in the midline areas of the brainstem in close association with the raphe nuclei (4). The exception is the serotonergic cell group in the ventrolateral midbrain, the B9 cell group (4). The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Neuroendocrine Pharmacology of Serotonergic (5-HT) Neurons

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Publisher
Annual Reviews
Copyright
Copyright 1991 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.31.040191.001445
pmid
2064377
Publisher site
See Article on Publisher Site

Abstract

Serotonergic neurons are believed to play a role in depression, anxiety, and aggression (for review see l ). There is evidence that serotonergic neurons send collaterals to limbic and neuroendocrine control areas in the brain (2-3). Consequently, hormones that are released by serotonergic neurons might serve as diagnostic tools to evaluate the serotonergic involvement in emotion­ al disorders. This review is a survey of the evidence for serotonergic regula­ tion of ACTH, {3-endorphin, prolactin, renin, oxytocin, vasopressin, growth hormone (GH), and luteinizing hormone (LH) secretion. The anatomy of the serotonergic pathways is discussed briefly , followed by a concise overview of the pharmacology of serotonergic neurotransmission. The evidence for a role of serotonergic neurons in the regulation of each individual hormone is divided into three sections: (a) the anatomical organization; (b) the physiolog­ ical function; and (c) the 5-HT receptor subtypes involved in the regulation of each hormone. 0362-1642/91/0415-0289$02.00 VAN DE KAR NEUROANATOMY OF BRAIN SEROTONERGIC NEURONS Serotonergic cell bodies, designated B1-B8 cell groups, are found in the midline areas of the brainstem in close association with the raphe nuclei (4). The exception is the serotonergic cell group in the ventrolateral midbrain, the B9 cell group (4). The

Journal

Annual Review of Pharmacology and ToxicologyAnnual Reviews

Published: Apr 1, 1991

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