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Metal Ion Sensors Based on DNAzymes and Related DNA Molecules

Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical sensors for metal ions, such as Pb 2+ , Cu 2+ , Hg 2+ , and UO 2 2+ . In addition, we also describe metal ion sensors based on related DNA molecules, including T-T or C-C mismatches and G-quadruplexes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Analytical Chemistry Annual Reviews
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