By SAUL ROSEMAN3 Rackham Arthritis Research! Unit and DePartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan This review will stress the metabolism of certain carbohydrate constiÂ tu ent s of connective tissue and related compounds. Only a few of the numerous pub li c at ion s in this field w ill be reviewed, because of limitations of space.4 CONNECflVE TISSUE There is apparently no exact definition of connective tissue (12, 13, 14). Robb-Smith regards co nnecti v e tissue as "a continuous fluid matrix varying in c o nsi s tency f rom the limpid Wharton's Jelly of the u mbilical cord to the hardness of bone, in which is lying an interlacing f ab ric of fibers of differÂ ent s o rts ... " (13). Thus, connective tissues from different area s of the body vary considerably in chemical composition, d espite the fact that the tissue is regard ed as "continuous." The composition of the tissue in certain areas also changes with age (15). Important physiological phenomena, such as the aging process, wound h eal ing, certain i mmunol ogical reactions, "connective tissue diseases," calcifiÂ cation and bone re sorption, apparently depend
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1959
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