Mechanisms of Cortical Development: A View From Mutations in Mice

Mechanisms of Cortical Development: A View From Mutations in Mice Cortical structures in the mammalian central nervous system are remarkable among elegance of forms, geometbiological tissues for the variety and elegance of their cellular forms, for the geomet­ of elements, ric regularity in the spatial arrangements of like and unlike neuronal elements, and heterogeneity of cells. modififor the heterogeneity in the types of interrelationships among cells. Complex modifi­ connectivity of cations in the structure and synaptic connectivity of the cortex may result from single loci. Structural modifications mutations at single genetic loci. Structural modifications induced by a mutation may specific be specific in character and often independent of variations in genetic background independent (e.g. Caviness, Sidman 1973c, 1976b, Sotelo 1972, (e,g. Caviness, So & Sidman 1972, Rakic & Sidman 1973c, Rakic 1976b, Sotelo 1975a, Mariani et al 1977). Various aspects of the effects of single gene mutations 1975a, a1 1977). aspects of of on the structure and function of the nervous system have been recently reviewed of system 1976, 1976. Cavi1972, 1974, (Sidman 1972, 1974, Rakic 1974b, 1976b, Pak & Pinto 1976, Goldman 1976, Cavi­ 1974b, 1976b, ness 1977, Drager 1977), 1977, 1977). specifically modifications The present review is concerned specifically with cellular modifications induced system in cortical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Neuroscience Annual Reviews

Mechanisms of Cortical Development: A View From Mutations in Mice

Annual Review of Neuroscience, Volume 1 (1) – Mar 1, 1978

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Publisher
Annual Reviews
Copyright
Copyright 1978 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0147-006X
eISSN
1545-4126
DOI
10.1146/annurev.ne.01.030178.001501
Publisher site
See Article on Publisher Site

Abstract

Cortical structures in the mammalian central nervous system are remarkable among elegance of forms, geometbiological tissues for the variety and elegance of their cellular forms, for the geomet­ of elements, ric regularity in the spatial arrangements of like and unlike neuronal elements, and heterogeneity of cells. modififor the heterogeneity in the types of interrelationships among cells. Complex modifi­ connectivity of cations in the structure and synaptic connectivity of the cortex may result from single loci. Structural modifications mutations at single genetic loci. Structural modifications induced by a mutation may specific be specific in character and often independent of variations in genetic background independent (e.g. Caviness, Sidman 1973c, 1976b, Sotelo 1972, (e,g. Caviness, So & Sidman 1972, Rakic & Sidman 1973c, Rakic 1976b, Sotelo 1975a, Mariani et al 1977). Various aspects of the effects of single gene mutations 1975a, a1 1977). aspects of of on the structure and function of the nervous system have been recently reviewed of system 1976, 1976. Cavi1972, 1974, (Sidman 1972, 1974, Rakic 1974b, 1976b, Pak & Pinto 1976, Goldman 1976, Cavi­ 1974b, 1976b, ness 1977, Drager 1977), 1977, 1977). specifically modifications The present review is concerned specifically with cellular modifications induced system in cortical

Journal

Annual Review of NeuroscienceAnnual Reviews

Published: Mar 1, 1978

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