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Inheritance of Immunity in Animals

Inheritance of Immunity in Animals By JOHN W. GOWEN Department of Genetics Iowa State College, Ames, Iowa Reactions characteristic of individuals within a species ex­ posed to pathogens may vary from those causing no effect to those causing death. All grades of effects between these extremes are observed. Morbidity of various degrees is ordinarily the most fre­ quent result. Unaffected individuals could be considered im­ munes, those which show morbidity to different degrees, resist­ ants, and those which die, susceptibles. Inheritance affects these reactions according to the processes necessary to bring about the disease. The normal organism is the resultant of the action of some thousands of genes (five thousand to thirty thousand, with possibly eight thousand as the likely number in Drosophila) [Gowen & Gay ( 1)]. The morbid condition may be due to a gene or group of genes substituted for the normal genes, their alleles, working on a substrate of tissue formed by the re­ maining normal genes. In this exchange the substituted gene is in truth the pathogen as it parasitizes the normal development of the host and leads to its death or unfitness for survival as con­ trasted with a host having the normal alleles. The severity of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Inheritance of Immunity in Animals

Gowen, J W
Annual Review of Microbiology , Volume 2 (1) – Oct 1, 1948
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Publisher
Annual Reviews
Copyright
Copyright 1948 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.02.100148.001243
pmid
18104347
Publisher site
See Article on Publisher Site

Abstract

By JOHN W. GOWEN Department of Genetics Iowa State College, Ames, Iowa Reactions characteristic of individuals within a species ex­ posed to pathogens may vary from those causing no effect to those causing death. All grades of effects between these extremes are observed. Morbidity of various degrees is ordinarily the most fre­ quent result. Unaffected individuals could be considered im­ munes, those which show morbidity to different degrees, resist­ ants, and those which die, susceptibles. Inheritance affects these reactions according to the processes necessary to bring about the disease. The normal organism is the resultant of the action of some thousands of genes (five thousand to thirty thousand, with possibly eight thousand as the likely number in Drosophila) [Gowen & Gay ( 1)]. The morbid condition may be due to a gene or group of genes substituted for the normal genes, their alleles, working on a substrate of tissue formed by the re­ maining normal genes. In this exchange the substituted gene is in truth the pathogen as it parasitizes the normal development of the host and leads to its death or unfitness for survival as con­ trasted with a host having the normal alleles. The severity of

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1948

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