Transcriptional regulation of the immunoglobulin (Ig) genes is one of the best-studied systems for understanding tissue-restricted gene control. Dissection of the Ig genes reveals that each contains multiple regulatory elements that are preferentially active in B lymphocytes. These include a promoter and one or more enhancer elements. Biochemical analysis and cloning of the genes for transactivator proteins has uncovered a variety of distinct proteins that are often members of gene families. The transÂ activators themselves are under complex regulation at the transcriptional level as well as by interactions with other proteins in the cell. It appears that the coordinate action of a select constellation of these transactivators conveys the information for tissue-specific expression of the Ig genes. INTRODUCTION B lymphocyte differentiation can be viewed as an ordered program of gene expression. This developmental process requires changes in transcriptional I The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. STAUDT & LENARDO activity at three critical steps: (a) commitment of a pluripotent hemaÂ topoietic stem cell to the B lymphoid lineage, (b) progression from the preÂ B-cell stage to the mature B-cell stage, and (c) terminal differentiation into
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1991
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