Immunoglobulin Gene Transcription

Immunoglobulin Gene Transcription Transcriptional regulation of the immunoglobulin (Ig) genes is one of the best-studied systems for understanding tissue-restricted gene control. Dissection of the Ig genes reveals that each contains multiple regulatory elements that are preferentially active in B lymphocytes. These include a promoter and one or more enhancer elements. Biochemical analysis and cloning of the genes for transactivator proteins has uncovered a variety of distinct proteins that are often members of gene families. The trans­ activators themselves are under complex regulation at the transcriptional level as well as by interactions with other proteins in the cell. It appears that the coordinate action of a select constellation of these transactivators conveys the information for tissue-specific expression of the Ig genes. INTRODUCTION B lymphocyte differentiation can be viewed as an ordered program of gene expression. This developmental process requires changes in transcriptional I The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. STAUDT & LENARDO activity at three critical steps: (a) commitment of a pluripotent hema­ topoietic stem cell to the B lymphoid lineage, (b) progression from the pre­ B-cell stage to the mature B-cell stage, and (c) terminal differentiation into http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Immunoglobulin Gene Transcription

Annual Review of Immunology, Volume 9 (1) – Apr 1, 1991

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Publisher
Annual Reviews
Copyright
Copyright 1991 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.09.040191.002105
Publisher site
See Article on Publisher Site

Abstract

Transcriptional regulation of the immunoglobulin (Ig) genes is one of the best-studied systems for understanding tissue-restricted gene control. Dissection of the Ig genes reveals that each contains multiple regulatory elements that are preferentially active in B lymphocytes. These include a promoter and one or more enhancer elements. Biochemical analysis and cloning of the genes for transactivator proteins has uncovered a variety of distinct proteins that are often members of gene families. The trans­ activators themselves are under complex regulation at the transcriptional level as well as by interactions with other proteins in the cell. It appears that the coordinate action of a select constellation of these transactivators conveys the information for tissue-specific expression of the Ig genes. INTRODUCTION B lymphocyte differentiation can be viewed as an ordered program of gene expression. This developmental process requires changes in transcriptional I The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. STAUDT & LENARDO activity at three critical steps: (a) commitment of a pluripotent hema­ topoietic stem cell to the B lymphoid lineage, (b) progression from the pre­ B-cell stage to the mature B-cell stage, and (c) terminal differentiation into

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1991

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