Immunoglobulin A: Strategic Defense Initiative at the Mucosal Surface

Immunoglobulin A: Strategic Defense Initiative at the Mucosal Surface IgA is the predominant immunoglobulin in the external secretions of humans. Specific IgA-producing cells home to mucosal epithelia through­ out the body to provide humoral protection as a frontline defense against pathogens borne in aerosols, the environment, and the diet. Much of the recent research on IgA has been directed toward three central questions: (a) What are the factors that account for the localization and regulation of IgA-producing cells at the mucosae; (b) What is the nature of the mechanism that selectively transports secretory IgA to the mucosal lumen; and (c) What are the physiologically important roles of IgA, both in blood and in the exocrine environment. Regulation of IgA production is an extensive topic in itself and will be touched on here only briefly. We concentrate on the fate and function of IgA after synthesis and try to assess which of its experimentally described properties are essential for IgA to contribute to the well-being of the host. SYNTHESIS AND STRUCTURE Lymphocyte Traffic and Immunoregulation IgA is produced by cells of the B-Iymphocyte lineage, both in the peripheral and mucosal lymphoid tissue. The functions of IgA in blood are poorly 389 0732-0582/86/0410-0389$02.00 UNDERDOWN & SCHIFF understood, and few http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Immunoglobulin A: Strategic Defense Initiative at the Mucosal Surface

Annual Review of Immunology, Volume 4 (1) – Apr 1, 1986

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
D.O.I.
10.1146/annurev.iy.04.040186.002133
Publisher site
See Article on Publisher Site

Abstract

IgA is the predominant immunoglobulin in the external secretions of humans. Specific IgA-producing cells home to mucosal epithelia through­ out the body to provide humoral protection as a frontline defense against pathogens borne in aerosols, the environment, and the diet. Much of the recent research on IgA has been directed toward three central questions: (a) What are the factors that account for the localization and regulation of IgA-producing cells at the mucosae; (b) What is the nature of the mechanism that selectively transports secretory IgA to the mucosal lumen; and (c) What are the physiologically important roles of IgA, both in blood and in the exocrine environment. Regulation of IgA production is an extensive topic in itself and will be touched on here only briefly. We concentrate on the fate and function of IgA after synthesis and try to assess which of its experimentally described properties are essential for IgA to contribute to the well-being of the host. SYNTHESIS AND STRUCTURE Lymphocyte Traffic and Immunoregulation IgA is produced by cells of the B-Iymphocyte lineage, both in the peripheral and mucosal lymphoid tissue. The functions of IgA in blood are poorly 389 0732-0582/86/0410-0389$02.00 UNDERDOWN & SCHIFF understood, and few

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1986

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