Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Ohashi, S. Oehen, K. Buerki, H. Pircher, C. Ohashi, B. Odermatt, B. Malissen, R. Zinkernagel, H. Hengartner (1991)
Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic miceCell, 65
M. Steinmetz, Leroy Hood (1984)
Molecular immunology: genes of the major histocompatibility complex of the mouseImmunogenetics
D. Jabs, C. Burek, Q. Hu, R. Kuppers, B. Lee, R. Prendergast (1992)
Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice.Cellular immunology, 141 2
D. Veis, C. Sorenson, J. Shutter, S. Korsmeyer (1993)
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairCell, 75
D. Raulet (1994)
MHC class I-deficient mice.Advances in immunology, 55
L. Berg, A. Pullen, B. Groth, D. Mathis, C. Benoist, Mark Davis (1989)
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligandCell, 58
Ellen Robey, Ellen Robey, B. Fowlkes, J. Gordon, D. Kioussis, H. Boehmer, F. Ramsdell, R. Axel (1991)
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineageCell, 64
C Guidos, J. Danska, C. Fathman, I Weissman (1990)
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineagesThe Journal of Experimental Medicine, 172
Anne Crump, M. Grusby, L. Glimcher, Harvey Cantor (1993)
Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.Proceedings of the National Academy of Sciences of the United States of America, 90 22
H. Auchincloss, Richard Lee, S. Shea, J. Markowitz, M. Grusby, L. Glimcher (1993)
The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.Proceedings of the National Academy of Sciences of the United States of America, 90
T Laufer, M. Herrath, M. Grusby, M Oldstone, L. Glimcher (1993)
Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient miceThe Journal of Experimental Medicine, 178
C. Sentman, J. Shutter, D. Hockenbery, O. Kanagawa, S. Korsmeyer (1991)
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytesCell, 67
M. Grusby, R. Johnson, VE Papaioannou, L. Glimcher (1991)
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient miceScience, 253
A. Kruisbeek, J. Mond, B. Fowlkes, J. Carmen, S. Bridges, D. Longo (1985)
Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A- bearing antigen-presenting cell functionThe Journal of Experimental Medicine, 161
Susan Chan, D. Cosgrove, C. Waltzinger, C. Benoist, D. Mathis (1993)
Another view of the selective model of thymocyte selectionCell, 73
Rie Watanabe‐Fukunaga, C. Brannan, N. Copeland, N. Jenkins, S. Nagata (1992)
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisNature, 356
D. Mathis, C. Benoist, nd Williams, M. Kanter, H. Mcdevitt (1983)
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.Proceedings of the National Academy of Sciences of the United States of America, 80 1
K. Suzuki (1983)
The twitcher mouse. A model of human globoid cell leukodystrophy (krabbe's disease).The American journal of pathology, 111 3
B. Koller, P. Marrack, J. Kappler, O. Smithies (1990)
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.Science, 248 4960
L. Duchen, E. Eicher, J. Jacobs, F. Scaravilli, F. Teixeira (1980)
Hereditary leucodystrophy in the mouse: the new mutant twitcher.Brain : a journal of neurology, 103 3
B. Koller, O. Smithies (1992)
Altering genes in animals by gene targeting.Annual review of immunology, 10
B. Sadlack, H. Merz, H. Schorle, A. Schimpl, A. Feller, I. Horak (1993)
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 geneCell, 75
D. Cosgrove, D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, D. Mathis (1991)
Mice lacking MHC class II moleculesCell, 66
G. Linette, M. Grusby, S. Hedrick, T. Hansen, L. Glimcher, S. Korsmeyer (1994)
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.Immunity, 1 3
M. Grusby, H. Auchincloss, Richard LEEt, Randall Johnson, James Spencer, M. Zijlstra, R. Jaenisch, E. Papaioannou, L. Glimcher (1993)
Mice lacking major histocompatibility complex class I and class II molecules.Proceedings of the National Academy of Sciences of the United States of America, 90
P. Borgulya, Hiroyuki Kishi, Urs Muller, J. Kirberg, H. Boehmer (1991)
Development of the CD4 and CD8 lineage of T cells: instruction versus selection.The EMBO Journal, 10
Major histocompatibility complex (MHC) class II molecules are heterodimeric cell surface proteins that are critically important for the development and function of cells in the immune system. In particular, the maturation of CD4+ T cells is dependent on the expression of MHC class II molecules on thymic epithelium, while the activation of these cells requires the expression of class II molecules on specialized antigen-presenting cells in the periphery. The importance of class II molecules is especially evident in humans who are afflicted with MHC class II-deficient combined immunodeficiency, as these individuals die at an early age unless provided with a bone marrow transplant. Here we discuss the functional consequences of MHC class II deficiency in a mouse model generated by gene targeting in embryonic stem (ES) cells. These mice have proved to be valuable reagents for dissecting the mechanisms by which MHC class II molecules control the maturation and activation of lymphocytes as well as for elucidating the role of these cells in various immune responses. INTRODUCTION As with any complex biological system, our understanding of the development and function of cells in the immune system has been aided by the study of mutants. For example, mice harboring
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.