Growth Factors in Milk as Mediators of Infant Development

Growth Factors in Milk as Mediators of Infant Development Growth factors are composed of a heterogeneous group of proteins and pep­ tides that initiate cellular growth and expression of differentiated function. Circulating growth factors may act in an analogous manner to classic endocrine hormones. In addition, most growth factors are synthesized in multiple cell types throughout the body and may act locally within a particular cell or upon adjacent cells via autocrine or paracrine mechanisms, respectively. In the 1970s and 1980s, researchers demonstrated that milk is a potent stimulator of growth both in vivo and in vitro. Widdowson et al (122) docu­ mented the marked increase in gastrointestinal (01) weight,length,and protein 0199-9885/9410715-0147$05.00 DONOVAN & ODLE and DNA content of colostrum-fed neonatal piglets in the first 24 h of life. More recent piglet studies have demonstrated stimulation of GI DNA (114) and protein synthesis (19) by both mature milk and, to a greater degree, colostrum. Colostrum-fed piglets also had greater fractional protein synthesis rates in liver, kidney, spleen, and skeletal muscle than piglets fed milk, which indicates that colostral factors may mediate growth of tissues outside of the GI tract (19). In 1978, Klagsbrun provided the first in vitro evidence that human milk contains mitogenic factors (58). At http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

Growth Factors in Milk as Mediators of Infant Development

Annual Review of Nutrition, Volume 14 (1) – Jul 1, 1994

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Publisher
Annual Reviews
Copyright
Copyright 1994 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0199-9885
eISSN
1545-4312
D.O.I.
10.1146/annurev.nu.14.070194.001051
Publisher site
See Article on Publisher Site

Abstract

Growth factors are composed of a heterogeneous group of proteins and pep­ tides that initiate cellular growth and expression of differentiated function. Circulating growth factors may act in an analogous manner to classic endocrine hormones. In addition, most growth factors are synthesized in multiple cell types throughout the body and may act locally within a particular cell or upon adjacent cells via autocrine or paracrine mechanisms, respectively. In the 1970s and 1980s, researchers demonstrated that milk is a potent stimulator of growth both in vivo and in vitro. Widdowson et al (122) docu­ mented the marked increase in gastrointestinal (01) weight,length,and protein 0199-9885/9410715-0147$05.00 DONOVAN & ODLE and DNA content of colostrum-fed neonatal piglets in the first 24 h of life. More recent piglet studies have demonstrated stimulation of GI DNA (114) and protein synthesis (19) by both mature milk and, to a greater degree, colostrum. Colostrum-fed piglets also had greater fractional protein synthesis rates in liver, kidney, spleen, and skeletal muscle than piglets fed milk, which indicates that colostral factors may mediate growth of tissues outside of the GI tract (19). In 1978, Klagsbrun provided the first in vitro evidence that human milk contains mitogenic factors (58). At

Journal

Annual Review of NutritionAnnual Reviews

Published: Jul 1, 1994

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