J. C Watkins Department of Physiology, The Medical School, University of Bristol, Bristol BS8 lTD, England R. H. Evans Department of Pharmacology, The Medical School. University of Bristol, Bristol BS8 lTD, England Since the more recent reviews on excitatory amino acid actions in the vertebrate central nervous system (1-5) there has been considerable progress along two particular investigative fronts, leading to firm concluÂ sions about amino acid-mediated synaptic excitation. These two apÂ proaches are, first, the development of new agonists and antagonists for determining the pharmacological properties of different excitatory amino acid receptors, and, second, the use of lesioning techniques to determine the effects of selective neuronal and/or afferent input loss upon regional levels, uptake, and release of suspected transmitters. A third technique in widespread use is the study of membrane binding sites for excitatory amino acids by the use of radioactive ligands. This review correlates the findings of these three different lines of research, and, in particular, highÂ lights gaps in the evidence for amino acid-mediated synaptic excitation in specific neuronal pathways. Prior to this, however, some recent neurochemical and pharmacological findings of more general relevance are discussed. 0362-1642/81/0415-0165$01.00 WATKINS & EVANS NEUROCHEMISTRY Putative Excitatory Amino Acid
Annual Review of Pharmacology and Toxicology – Annual Reviews
Published: Apr 1, 1981
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