Excitatory Amino Acid Transmitters

Excitatory Amino Acid Transmitters J. C Watkins Department of Physiology, The Medical School, University of Bristol, Bristol BS8 lTD, England R. H. Evans Department of Pharmacology, The Medical School. University of Bristol, Bristol BS8 lTD, England Since the more recent reviews on excitatory amino acid actions in the vertebrate central nervous system (1-5) there has been considerable progress along two particular investigative fronts, leading to firm conclu­ sions about amino acid-mediated synaptic excitation. These two ap­ proaches are, first, the development of new agonists and antagonists for determining the pharmacological properties of different excitatory amino acid receptors, and, second, the use of lesioning techniques to determine the effects of selective neuronal and/or afferent input loss upon regional levels, uptake, and release of suspected transmitters. A third technique in widespread use is the study of membrane binding sites for excitatory amino acids by the use of radioactive ligands. This review correlates the findings of these three different lines of research, and, in particular, high­ lights gaps in the evidence for amino acid-mediated synaptic excitation in specific neuronal pathways. Prior to this, however, some recent neurochemical and pharmacological findings of more general relevance are discussed. 0362-1642/81/0415-0165$01.00 WATKINS & EVANS NEUROCHEMISTRY Putative Excitatory Amino Acid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Excitatory Amino Acid Transmitters

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Publisher
Annual Reviews
Copyright
Copyright 1981 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.21.040181.001121
Publisher site
See Article on Publisher Site

Abstract

J. C Watkins Department of Physiology, The Medical School, University of Bristol, Bristol BS8 lTD, England R. H. Evans Department of Pharmacology, The Medical School. University of Bristol, Bristol BS8 lTD, England Since the more recent reviews on excitatory amino acid actions in the vertebrate central nervous system (1-5) there has been considerable progress along two particular investigative fronts, leading to firm conclu­ sions about amino acid-mediated synaptic excitation. These two ap­ proaches are, first, the development of new agonists and antagonists for determining the pharmacological properties of different excitatory amino acid receptors, and, second, the use of lesioning techniques to determine the effects of selective neuronal and/or afferent input loss upon regional levels, uptake, and release of suspected transmitters. A third technique in widespread use is the study of membrane binding sites for excitatory amino acids by the use of radioactive ligands. This review correlates the findings of these three different lines of research, and, in particular, high­ lights gaps in the evidence for amino acid-mediated synaptic excitation in specific neuronal pathways. Prior to this, however, some recent neurochemical and pharmacological findings of more general relevance are discussed. 0362-1642/81/0415-0165$01.00 WATKINS & EVANS NEUROCHEMISTRY Putative Excitatory Amino Acid

Journal

Annual Review of Pharmacology and ToxicologyAnnual Reviews

Published: Apr 1, 1981

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