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Endorphins and Behavior

"None of them spoke much . . . A curious, dreamy, irresponsible feeling crept over them. It was as if they had all taken some narcotic drug-the merciful anodyne [analgesic] which Nature uses when a great crisis has fretted the nerves too far ... A subtle sweetness mingled with the sadness of their fate. They were filled with the serenity of despair." A. C. Doyle. The tragedy of the Korosko. The Strand Magazine, Sept. 1897. 0066-4308/82/0201-0087$02.00 BOLLES & FANSELOW Just a few years ago, Pert & Snyder (1973) reported that certain areas of the brain are peculiarly sensitive to opiates (e.g. morphine) and opiate antagonists (e.g. naloxone). The critical areas were soon implicated in a variety of pain mechanisms (see Liebeskind & Paul 1977), so that part of the puzzle began to go together. But there was a more difficult, and still largely unresolved, question-why? The pharmacological paradigm re­ quired that these areas contain opiate receptors. But why should there be opiate receptors anywhere in the brain? If their existence meant that there are opiate-like substances normally occurring in the brain, why were such substances there? What is their function? The next step was taken by Hughes and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Psychology Annual Reviews
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