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into the in testine hydrochloric acid (pH between 6.5 and 2.5) had a pepsi gogue effect on the gastric secretion produced in dogs by feeding BABKIN AND FRIEDMAN or by insulin but not on the secretion evoked by histamine. If the pH of the acid was below 2.5, the secretion of pepsin as well as that of acid was depressed (25, 26). Parathyreokrin, administered subcutaneously, diminished gas tric secretion and motility in dogs. A prep aration of the parathy roid glands lowered the gastric acidity in 50 per cent of cases in patients with hyperacidity (27). Parenteral administration of pituitrin or of "hypophysolysate" inhibited gastric secretion and increased the hunger contractions in dogs. In patients with hyper acidity the same substances lowered the gastric acidity and eliminated constipation in 50 per cent of cases (28). Repeated injection of mecholyl produced an abundant secre tion of acid gastric juice rich in pepsin, whereas a large single dose evoked a scanty secretion of low acidity but high peptic power. The pyloric portion of the stomach responded to mecholyl with a sec retion of alkaline mucus devoid of pepsin (29). Caffeine does not elicit gastric secretion in dogs, but when introduced
Annual Review of Physiology – Annual Reviews
Published: Mar 1, 1945
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