The Epstein-B virus (EBV) has been associated with classic infectious arr mononucleosis, B urkitt's lymphoma, nasopharyngeal carcinoma, and B Â cell lymphomas in primary and secondary immunodeficiency disease. The availability of specific serologic diagnosis of EBV, rather than dependence on heterophile antibody positivity, has broadened the scope of EBVÂ associated diseases. A chronic neuroasthenia syndrome accompanied by antibody titers to the viral capsid antigen and early antigen of EBV, which are higher than found in asymptomatic'''individuals, is one such additional EBV-associated syndrome. This paper describes the clinical and laboratory responses to EBV that are present in this chronic syndrome. It then discusses management of these patients and the difficulties in establishing a cause-and-effect relationship between EBV and chronic neuroasthenia along with recommendations for future studies. INTRODUCTION Epstein-Barr virus (EBV) is the major cause of acute infectious mononuÂ cleosis (1) and is associated with a wide spectrum of benign to malignant hematologic and lymphoproliferative disorders (2-5). Within the past few I The US Government has the right to retain a nonexclusive. royalty-free license in and to any copyright covering this paper. JONES & STRAUS years a series of studies has suggested that the known list ofEBV-associated disorders should include
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1987
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