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Chronic Epstein-Barr Virus Infection

Chronic Epstein-Barr Virus Infection The Epstein-B virus (EBV) has been associated with classic infectious arr mononucleosis, B urkitt's lymphoma, nasopharyngeal carcinoma, and B ­ cell lymphomas in primary and secondary immunodeficiency disease. The availability of specific serologic diagnosis of EBV, rather than dependence on heterophile antibody positivity, has broadened the scope of EBV­ associated diseases. A chronic neuroasthenia syndrome accompanied by antibody titers to the viral capsid antigen and early antigen of EBV, which are higher than found in asymptomatic'''individuals, is one such additional EBV-associated syndrome. This paper describes the clinical and laboratory responses to EBV that are present in this chronic syndrome. It then discusses management of these patients and the difficulties in establishing a cause-and-effect relationship between EBV and chronic neuroasthenia along with recommendations for future studies. INTRODUCTION Epstein-Barr virus (EBV) is the major cause of acute infectious mononu­ cleosis (1) and is associated with a wide spectrum of benign to malignant hematologic and lymphoproliferative disorders (2-5). Within the past few I The US Government has the right to retain a nonexclusive. royalty-free license in and to any copyright covering this paper. JONES & STRAUS years a series of studies has suggested that the known list ofEBV-associated disorders should include http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Chronic Epstein-Barr Virus Infection

Annual Review of Medicine , Volume 38 (1) – Feb 1, 1987

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Publisher
Annual Reviews
Copyright
Copyright 1987 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.38.020187.001211
pmid
3034134
Publisher site
See Article on Publisher Site

Abstract

The Epstein-B virus (EBV) has been associated with classic infectious arr mononucleosis, B urkitt's lymphoma, nasopharyngeal carcinoma, and B ­ cell lymphomas in primary and secondary immunodeficiency disease. The availability of specific serologic diagnosis of EBV, rather than dependence on heterophile antibody positivity, has broadened the scope of EBV­ associated diseases. A chronic neuroasthenia syndrome accompanied by antibody titers to the viral capsid antigen and early antigen of EBV, which are higher than found in asymptomatic'''individuals, is one such additional EBV-associated syndrome. This paper describes the clinical and laboratory responses to EBV that are present in this chronic syndrome. It then discusses management of these patients and the difficulties in establishing a cause-and-effect relationship between EBV and chronic neuroasthenia along with recommendations for future studies. INTRODUCTION Epstein-Barr virus (EBV) is the major cause of acute infectious mononu­ cleosis (1) and is associated with a wide spectrum of benign to malignant hematologic and lymphoproliferative disorders (2-5). Within the past few I The US Government has the right to retain a nonexclusive. royalty-free license in and to any copyright covering this paper. JONES & STRAUS years a series of studies has suggested that the known list ofEBV-associated disorders should include

Journal

Annual Review of MedicineAnnual Reviews

Published: Feb 1, 1987

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