The discovery by Tranzer & Thoenen (1967) that the noradrenaline (NA) analogue 6-hydroxydopamine (6-0H-DA; 2.4,5-trihydroxyphenylethylaÂ mine) can induce selective degeneration of sympathetic adrenergic nerves led to the introduction of a new concept into neurobiology, namely chemical denervation of a given neuron type. The rationale for this site- or targetÂ directed neurotoxic action is that 6-0H-DA is a generally cytotoxic agent that is selectively accumulated by catecholamine (CA) neurons, thereby restricting the degenerative action of the compound to the structures that accumulate it. This principle was later extended to 5-hydroxytryplamine (5-HT; serotonin) neurons which are acted on by 5,6- and 5,7-dihydroxyÂ tryptamine (5,6-HT; 5,7-HT) in the same way (Baumgarten et aI 1971, 1973, Baumgarten & Lachenmayer1972). The discovery of these neurotoxÂ ins opened new opportunities and they have over the years been extensively used as denervation tools for morphological, biochemical, physiological, pharmacological, and behavioral investigations to elucidate various aspects of monoamine neurotransmitter functions (see Malmfors & Thoenen 1971, Jonsson et al1975, Sachs & Jonsson 1975a, Kostrzewa & Jacobowitz1974, Baumgarten & Bjorklund 1976, Baumgarten et al 1977, Jacoby & Lytle 1978). This development has also led to much greater awareness of potenÂ tially cytotoxic agents and a number of structurally
Annual Review of Neuroscience – Annual Reviews
Published: Mar 1, 1980
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