Cell Surface Interactions with Extracellular Materials

Cell Surface Interactions with Extracellular Materials The composition of extracellular materials interacting with the cell surface has important regulatory and structural consequences for cells, and an extensive literature now documents these biological roles (reviewed in 1-9). Several dramatic examples show the regulation of cell morphology, cytoskeletal organization, and even cell type by purified extracellular macromolecules. Treatment by purified cellular fibronectin of oncogeni­ cally transformed cells originally deficient in fibronectin can restore normal cell shape, adhesiveness, cell surface morphology, and actin microfilament organization (13-15); similarly, dissociated epithelial cells cease blebbing and reorganize cortical microfilaments after treatment with purified fibronectin, laminin, or collagen (16). Exposure of cartilage chondrocytes to purified cellular fibronectin alters their morphology and patterns of biosynthesis, causing a reversion from chondrocyte-specific synthesis of type II collagen and proteoglycans to a mesenchymal-cell pattern ( 1 7, 1 8). A particularly striking change was obs�rved when fully differentiated epi­ thelial cells were cultured within a gel of purified collagen. The cells underwent a fundamental alteration in phenotype from epithelial to mesenchymal cell ( 1 9). This alteration was accompanied by major changes in cell interactions and morphology, so that cells migrate away from epithelial sheets to form isolated bipolar cells that can invade collagen gels http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Cell Surface Interactions with Extracellular Materials

Annual Review of Biochemistry, Volume 52 (1) – Jul 1, 1983

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Publisher
Annual Reviews
Copyright
Copyright 1983 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.52.070183.003553
pmid
6351729
Publisher site
See Article on Publisher Site

Abstract

The composition of extracellular materials interacting with the cell surface has important regulatory and structural consequences for cells, and an extensive literature now documents these biological roles (reviewed in 1-9). Several dramatic examples show the regulation of cell morphology, cytoskeletal organization, and even cell type by purified extracellular macromolecules. Treatment by purified cellular fibronectin of oncogeni­ cally transformed cells originally deficient in fibronectin can restore normal cell shape, adhesiveness, cell surface morphology, and actin microfilament organization (13-15); similarly, dissociated epithelial cells cease blebbing and reorganize cortical microfilaments after treatment with purified fibronectin, laminin, or collagen (16). Exposure of cartilage chondrocytes to purified cellular fibronectin alters their morphology and patterns of biosynthesis, causing a reversion from chondrocyte-specific synthesis of type II collagen and proteoglycans to a mesenchymal-cell pattern ( 1 7, 1 8). A particularly striking change was obs�rved when fully differentiated epi­ thelial cells were cultured within a gel of purified collagen. The cells underwent a fundamental alteration in phenotype from epithelial to mesenchymal cell ( 1 9). This alteration was accompanied by major changes in cell interactions and morphology, so that cells migrate away from epithelial sheets to form isolated bipolar cells that can invade collagen gels

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1983

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