Cell Migration in the Vertebrate Embryo: Role of Cell Adhesion and Tissue Environment in Pattern Formation

Cell Migration in the Vertebrate Embryo: Role of Cell Adhesion and Tissue Environment in Pattern... The development of an embryo results from a series of highly intercon­ nected and complex processes. The detailed program used by the ferti91 0743-4634/85/1115-D091$02.00 THIERY, DUBAND & TUCKER tized egg differs considerably in different species, however, some general principles of development contribute to the elaboration of the body plan. One of the most general features resides in the considerable discrepancy between the fate map of the blastoderm and the definitive location of the different tissues. This drastic reorganization of the presumptive territories in the young embryo results primarily from extensive morphogenetic movements, including individual cell migration and cell sheet spreading, during gastrulation. These various movements allow the transformation of the blastula into a three-layered embryo, and also contribute to the induction and shaping of the nervous system. In this chapter we examine the migration of cells during gastrulation, and the subsequent emigration of some cells from the neural primordium to give rise to the peripheral nervous system. Our analysis focuses on the mechanisms that provide directionality for the migrating cells, as well as on the adhesive interactions that control cell behavior. The ability of other cell types to respond to different cues is discussed to help define the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cell and Developmental Biology Annual Reviews

Cell Migration in the Vertebrate Embryo: Role of Cell Adhesion and Tissue Environment in Pattern Formation

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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
1081-0706
eISSN
1530-8995
DOI
10.1146/annurev.cb.01.110185.000515
Publisher site
See Article on Publisher Site

Abstract

The development of an embryo results from a series of highly intercon­ nected and complex processes. The detailed program used by the ferti91 0743-4634/85/1115-D091$02.00 THIERY, DUBAND & TUCKER tized egg differs considerably in different species, however, some general principles of development contribute to the elaboration of the body plan. One of the most general features resides in the considerable discrepancy between the fate map of the blastoderm and the definitive location of the different tissues. This drastic reorganization of the presumptive territories in the young embryo results primarily from extensive morphogenetic movements, including individual cell migration and cell sheet spreading, during gastrulation. These various movements allow the transformation of the blastula into a three-layered embryo, and also contribute to the induction and shaping of the nervous system. In this chapter we examine the migration of cells during gastrulation, and the subsequent emigration of some cells from the neural primordium to give rise to the peripheral nervous system. Our analysis focuses on the mechanisms that provide directionality for the migrating cells, as well as on the adhesive interactions that control cell behavior. The ability of other cell types to respond to different cues is discussed to help define the

Journal

Annual Review of Cell and Developmental BiologyAnnual Reviews

Published: Nov 1, 1985

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