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Cardiovascular Pharmacology

Cardiovascular Pharmacology By GEORGE FAWAZ Department of Pharmacology, American Unillersity of Beirut, School of Medicine, Beirut, Lebanon Cardiovascular pharmacology, like other biological disciplines, is not free from controversy. Part of this, which might well be avoidable, is the result of such as the following: free application to the intact animal of results obtained on isolated organs and tissues; underestimation of species differ­ ences as well as the effect of anesthetics; insufficient appreciation of the influ­ ence of dosage and method of administration of drugs. It is not uncommon to observe one effect at low concentrations and an entirely opposite effect with higher dosages even on the same segment of the cardiovascular system. Mellander ( 1 ) , for example, found that intravenous epinephrine (E) infusion at the rate of OAl'g/kg/min resulted in marked dilatation of the "resistance" vessels of a skin-muscle region, but no change in or even slight constriction of "capacitance" vessels, while with 1 fJ.g there was a definite, and with 5 fJ.g a marked constriction of both resistance and capacitance vessels. These results are in harmony with observations on man where minimal doses of E may reduce the diastolic pressure while large doses raise it. Differences in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Cardiovascular Pharmacology

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Publisher
Annual Reviews
Copyright
Copyright 1963 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.03.040163.000421
Publisher site
See Article on Publisher Site

Abstract

By GEORGE FAWAZ Department of Pharmacology, American Unillersity of Beirut, School of Medicine, Beirut, Lebanon Cardiovascular pharmacology, like other biological disciplines, is not free from controversy. Part of this, which might well be avoidable, is the result of such as the following: free application to the intact animal of results obtained on isolated organs and tissues; underestimation of species differ­ ences as well as the effect of anesthetics; insufficient appreciation of the influ­ ence of dosage and method of administration of drugs. It is not uncommon to observe one effect at low concentrations and an entirely opposite effect with higher dosages even on the same segment of the cardiovascular system. Mellander ( 1 ) , for example, found that intravenous epinephrine (E) infusion at the rate of OAl'g/kg/min resulted in marked dilatation of the "resistance" vessels of a skin-muscle region, but no change in or even slight constriction of "capacitance" vessels, while with 1 fJ.g there was a definite, and with 5 fJ.g a marked constriction of both resistance and capacitance vessels. These results are in harmony with observations on man where minimal doses of E may reduce the diastolic pressure while large doses raise it. Differences in

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1963

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