Despite an extensive research effort over the last few decades, underÂ standing of how the central nervous system (CNS)! controls the circulation is at best still incomplete. Many symposia and reviews have detailed the function of catecholaminergic (CCA) pathways in the central connections of the autonomic nervous system (1-6). It is widely recognized that several methodological advances [e.g. chemical ablation by 6-hydroxydopamine (6-0HDA), sensitive and selective methods for detection and quantitation of CCA, use of specific substances which can alter formation, metabolism or release of catecholamines], paralleled by the development of drugs which lower blood pressure (BP) through stimulation of central adrenergic recepÂ tor sites (e.g. alpha-methyldopa, clonidine), have fostered precocious adÂ vances involving the biogenic amines. Until recently, however, far less IAbbreviations used in this paper: ACh, acetylcholine; AChE, acetylcholinesterase; ADH, antidiuretic hormone; BP, blood pressure; CAOR, carotid arterial occlusion reflex; CCA, catecholamine(rgic); ChAT, choline acetyltransferase; CNS, central nervous system; CV, carÂ diovascular; DFP, diisopropylfluorophosphate; DMPP, dimethylphenylpiperazinium; HR, heart rate; HC-3, hemicholinium-3; 6.0HDA, 6Â·hydroxydopamine; ia, intraarterial(ly); ic, intracistemal(ly); ica, intracarotid arterial(ly); icv; intracerebroventricular(ly); iv, intravenousÂ (ly); iva, intravertebral arterial(ly); LC, locus coeruleus; LV, lateral ventricle; NE, norepinephÂ rine; aud NTS, nucleus tractus solitarius; PHN, posterior hypothalamic nucleus;
Annual Review of Pharmacology and Toxicology – Annual Reviews
Published: Apr 1, 1982
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