Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous System

Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous System Despite an extensive research effort over the last few decades, under­ standing of how the central nervous system (CNS)! controls the circulation is at best still incomplete. Many symposia and reviews have detailed the function of catecholaminergic (CCA) pathways in the central connections of the autonomic nervous system (1-6). It is widely recognized that several methodological advances [e.g. chemical ablation by 6-hydroxydopamine (6-0HDA), sensitive and selective methods for detection and quantitation of CCA, use of specific substances which can alter formation, metabolism or release of catecholamines], paralleled by the development of drugs which lower blood pressure (BP) through stimulation of central adrenergic recep­ tor sites (e.g. alpha-methyldopa, clonidine), have fostered precocious ad­ vances involving the biogenic amines. Until recently, however, far less IAbbreviations used in this paper: ACh, acetylcholine; AChE, acetylcholinesterase; ADH, antidiuretic hormone; BP, blood pressure; CAOR, carotid arterial occlusion reflex; CCA, catecholamine(rgic); ChAT, choline acetyltransferase; CNS, central nervous system; CV, car­ diovascular; DFP, diisopropylfluorophosphate; DMPP, dimethylphenylpiperazinium; HR, heart rate; HC-3, hemicholinium-3; 6.0HDA, 6·hydroxydopamine; ia, intraarterial(ly); ic, intracistemal(ly); ica, intracarotid arterial(ly); icv; intracerebroventricular(ly); iv, intravenous­ (ly); iva, intravertebral arterial(ly); LC, locus coeruleus; LV, lateral ventricle; NE, norepineph­ rine; aud NTS, nucleus tractus solitarius; PHN, posterior hypothalamic nucleus; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous System

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Publisher
Annual Reviews
Copyright
Copyright 1982 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.22.040182.002013
pmid
7044289
Publisher site
See Article on Publisher Site

Abstract

Despite an extensive research effort over the last few decades, under­ standing of how the central nervous system (CNS)! controls the circulation is at best still incomplete. Many symposia and reviews have detailed the function of catecholaminergic (CCA) pathways in the central connections of the autonomic nervous system (1-6). It is widely recognized that several methodological advances [e.g. chemical ablation by 6-hydroxydopamine (6-0HDA), sensitive and selective methods for detection and quantitation of CCA, use of specific substances which can alter formation, metabolism or release of catecholamines], paralleled by the development of drugs which lower blood pressure (BP) through stimulation of central adrenergic recep­ tor sites (e.g. alpha-methyldopa, clonidine), have fostered precocious ad­ vances involving the biogenic amines. Until recently, however, far less IAbbreviations used in this paper: ACh, acetylcholine; AChE, acetylcholinesterase; ADH, antidiuretic hormone; BP, blood pressure; CAOR, carotid arterial occlusion reflex; CCA, catecholamine(rgic); ChAT, choline acetyltransferase; CNS, central nervous system; CV, car­ diovascular; DFP, diisopropylfluorophosphate; DMPP, dimethylphenylpiperazinium; HR, heart rate; HC-3, hemicholinium-3; 6.0HDA, 6·hydroxydopamine; ia, intraarterial(ly); ic, intracistemal(ly); ica, intracarotid arterial(ly); icv; intracerebroventricular(ly); iv, intravenous­ (ly); iva, intravertebral arterial(ly); LC, locus coeruleus; LV, lateral ventricle; NE, norepineph­ rine; aud NTS, nucleus tractus solitarius; PHN, posterior hypothalamic nucleus;

Journal

Annual Review of Pharmacology and ToxicologyAnnual Reviews

Published: Apr 1, 1982

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