Assembly of Asparagine-Linked Oligosaccharides

Assembly of Asparagine-Linked Oligosaccharides PERSPECTIVES AND SUMMARY The subject of asparagine-linked oligosaccharide synthesis and processing was last reviewed in this series in 1 9 8 1 by Hubbard & Ivatt (1). These authors concluded their excellent chapter with the following statement: "Although the main outlines of this pathway are now clear, several areas, including the detailed enzymology of the synthesizing and processing enzymes, the orga­ nization of these enzymes in the cell, the regulation of the pathway, and the 631 0066-4 1 54/85/0701 -063 1 $02.00 KORNFELD & KORNFELD factors that direct the terminal processing reactions are only beginning to be understood. " During the past few years considerable progress has been made in each of these areas. In addition, much new information has accumulated on the occur­ rence of oligosaccharide processing in the animal and plant kingdoms and on the repertoire of asparagine-linked oligosaccharides that are synthesized in nature. In this review we have attempted to focus on this new information, particularly the factors that serve to control the extent of processing and thereby determine the final oligosaccharide structures that are assembled. We will begin with a brief review of asparagine-linked oligosaccharide structure, in­ cluding examples of recently deduced structures. Due http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Assembly of Asparagine-Linked Oligosaccharides

Annual Review of Biochemistry, Volume 54 (1) – Jul 1, 1985

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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.54.070185.003215
pmid
3896128
Publisher site
See Article on Publisher Site

Abstract

PERSPECTIVES AND SUMMARY The subject of asparagine-linked oligosaccharide synthesis and processing was last reviewed in this series in 1 9 8 1 by Hubbard & Ivatt (1). These authors concluded their excellent chapter with the following statement: "Although the main outlines of this pathway are now clear, several areas, including the detailed enzymology of the synthesizing and processing enzymes, the orga­ nization of these enzymes in the cell, the regulation of the pathway, and the 631 0066-4 1 54/85/0701 -063 1 $02.00 KORNFELD & KORNFELD factors that direct the terminal processing reactions are only beginning to be understood. " During the past few years considerable progress has been made in each of these areas. In addition, much new information has accumulated on the occur­ rence of oligosaccharide processing in the animal and plant kingdoms and on the repertoire of asparagine-linked oligosaccharides that are synthesized in nature. In this review we have attempted to focus on this new information, particularly the factors that serve to control the extent of processing and thereby determine the final oligosaccharide structures that are assembled. We will begin with a brief review of asparagine-linked oligosaccharide structure, in­ cluding examples of recently deduced structures. Due

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1985

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