Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Active Oxygen Species and the Functions of Phagocytic Leukocytes

Active Oxygen Species and the Functions of Phagocytic Leukocytes PERSPECTIVES AND SUMMARY Phagocytosis is the process whereby certain cells convey solid objects from the external milieu to their interior, and then subject those objects, which are surrounded by an envelope of plasma membrane (the phagosome), to chemical and enzymatic attack. Cells that can perform this function are termed "phagocytes." The process is analogous to pinocytosis, the bulk transport of fluid into cells, and both are aspects of the more general process, "endocytosis," which was recently reviewed (1). Phagocytosis, the cellular events that occur just before, during, and just after the actual ingestion of particles, has long been recognized as a key process in combat­ ting infections in man and animals, and granulocytes (polymorphonuclear leukocytes), macrophages, and eosinophiles are of particular importance in this context. The process is one of interest to biochemists since the cellular membrane is crucially involved in the overall process, and membrane biochemistry is currently a very active field. Furthermore, essential functions of phagocytic leukocytes depend heavily on the enhanced production of hydrogen perox­ ide and superoxide anion (as well as other oxygen radicals) during phagocytosis. Elegant work on fundamental general aspects of superoxide anion, largely from the laboratory of Fridovich (2), has loosed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Active Oxygen Species and the Functions of Phagocytic Leukocytes

Badwey, J A; Karnovsky, M L
Annual Review of Biochemistry , Volume 49 (1) – Jul 1, 1980
Download PDF
32 pages

Loading next page...
 
/lp/annual-reviews/active-oxygen-species-and-the-functions-of-phagocytic-leukocytes-wI4Kq82M0I

References (1)

Publisher
Annual Reviews
Copyright
Copyright 1980 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.49.070180.003403
pmid
6250449
Publisher site
See Article on Publisher Site

Abstract

PERSPECTIVES AND SUMMARY Phagocytosis is the process whereby certain cells convey solid objects from the external milieu to their interior, and then subject those objects, which are surrounded by an envelope of plasma membrane (the phagosome), to chemical and enzymatic attack. Cells that can perform this function are termed "phagocytes." The process is analogous to pinocytosis, the bulk transport of fluid into cells, and both are aspects of the more general process, "endocytosis," which was recently reviewed (1). Phagocytosis, the cellular events that occur just before, during, and just after the actual ingestion of particles, has long been recognized as a key process in combat­ ting infections in man and animals, and granulocytes (polymorphonuclear leukocytes), macrophages, and eosinophiles are of particular importance in this context. The process is one of interest to biochemists since the cellular membrane is crucially involved in the overall process, and membrane biochemistry is currently a very active field. Furthermore, essential functions of phagocytic leukocytes depend heavily on the enhanced production of hydrogen perox­ ide and superoxide anion (as well as other oxygen radicals) during phagocytosis. Elegant work on fundamental general aspects of superoxide anion, largely from the laboratory of Fridovich (2), has loosed

Journal

Annual Review of Biochemistry – Annual Reviews

Published: Jul 1, 1980

There are no references for this article.