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luminal proteins from mice fed a control or a copper -deficient diet showed elevated levels of both total and apical membrane Ctr1 protein in response to transient dietary copper limitation. Experiments ...
Placeholder Text WorldCat Y. M. Kuo , A. A. Gybina, J. W. Pyatskowit, J. Gitschier and J. R. Prohaska Copper transport protein ( Ctr1 ) levels in mice are tissue specific and dependent on copper status , J. Nutr ...
An imbalance in copper (Cu) tissue homeostasis has a degenerative effect on spermatogenesis and male fertility. The high-affinity Cu transporter 1 ( CTR1 ; SLC31A1) is the major protein responsible ...
by a temporal decrease in COX activity and copper levels in the longer-lived Sco1stm/stm mice . Interestingly, the reduction in copper content of Sco1stm/stm cardiomyocytes was due to the mislocalisation of CTR1 ...
dysfunction. The copper (Cu) transporter 1 ( CTR1 , SLC31A1) protein is well-known to play a pivotal role in facilitating the uptake of cDDP into cells that allows for intracellular levels that ultimately result ...
that dietary copper deficiency did not change the protein levels of CTR1 and COX17, but increased CCS-1 protein levels in rat cardiac tissue .15 And another study also indicated that dietary copper ...
of proteins .1 Copper import is primarily mediated by proteins belonging to the copper transporter (CTR) family: high- and low-affinity transporters : CTR1 (encoded by Slc31a1 gene) and CTR2 (encoded by Slc31a2 ...
importance of CTR1 -mediated Cu uptake is further illustrated by embryonic lethality of the CTR1 knockout mice2 and marked pathologic changes in a cardiac tissue of mice with a targeted deletion of CTR1 ...
) This study Open in new tab 3.2 Tissue distribution of Cu transporters and corresponding change in expression levels upon Cu exposure The expression profiles of ATOX1, ATP7A, ATP7B, and CTR1 in the gills, heart ...
-/- brains was seen at 20 weeks (Fig 2B). Download: PPT PowerPoint slide PNG larger image TIFF original image Fig 2. Atp7b-/- mice brain show a tissue - specific Cu deficit at 4 weeks after birth (a) Cu levels ...
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