-
J.
Robertson,
P.
Jensen,
B.
Evavold
(2000)
DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323–339 Epitope1
The Journal of Immunology, 164
-
S.
Tsai,
Y.
Liaw,
Chen
Mh,
Huang
Cy,
Kuo
Gc
(1997)
Detection of type 2‐like T‐helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
Hepatology, 25
-
Yiping
Yang,
Yiping
Yang,
H.
Ertl,
J.
Wilson
(1994)
MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.
Immunity, 1 5
-
S.
Guerder,
E.
Eynon,
R.
Flavell
(1998)
Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.
Journal of immunology, 161 5
-
V.
Burgio,
G.
Ballardini,
M.
Artini,
M.
Caratozzolo,
F.
Bianchi,
M.
Levrero
(1998)
Expression of co‐stimulatory molecules by kupffer cells in chronic hepatitis of hepatitis C virus etiology
Hepatology, 27
-
T.
Wakita,
A.
Katsume,
J.
Kato,
C.
Taya,
H.
Yonekawa,
Y.
Kanegae,
I.
Saito,
Y.
Hayashi,
M.
Koike,
M.
Miyamoto,
Y.
Hiasa,
M.
Kohara
(2000)
Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system
Journal of Medical Virology, 62
-
A.
Bon,
N.
Etchart,
C.
Rossmann,
M.
Ashton,
S.
Hou,
D.
Gewert,
P.
Borrow,
D.
Tough
(2003)
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
Nature Immunology, 4
-
T.
Kafri,
D.
Morgan,
T.
Krahl,
N.
Sarvetnick,
L.
Sherman,
Inder
Verma
(1998)
Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America, 95 19
-
M.
Peitz,
K.
Pfannkuche,
K.
Rajewsky,
F.
Edenhofer
(2002)
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes
Proceedings of the National Academy of Sciences of the United States of America, 99
-
Catherine
Bigger,
K.
Brasky,
R.
Lanford
(2001)
DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection
Journal of Virology, 75
-
P.
Bertolino,
D.
Bowen,
G.
McCaughan,
B.
Groth
(2001)
Antigen-Specific Primary Activation of CD8+ T Cells Within the Liver1
The Journal of Immunology, 166
-
A.
Muir,
J.
Bornstein,
P.
Killenberg
(2004)
Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites.
The New England journal of medicine, 350 22
-
C.
Gremion,
B.
Grabscheid,
B.
Wölk,
D.
Moradpour,
J.
Reichen,
W.
Pichler,
A.
Cerny
(2004)
Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction
Journal of Virology, 78
-
A.
Grakoui,
N.
Shoukry,
D.
Woollard,
Jin-Hwan
Han,
H.
Hanson,
J.
Ghrayeb,
K.
Murthy,
C.
Rice,
C.
Walker
(2003)
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
Science, 302
-
Mounia
Tannour‐Louet,
A.
Porteu,
S.
Vaulont,
A.
Kahn,
M.
Vasseur-Cognet
(2002)
A tamoxifen‐inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver
Hepatology, 35
-
T.
Sparer,
S.
Wynn,
D.
Clark,
J.
Kaplan,
L.
Cardoza,
S.
Wadsworth,
A.
Smith,
L.
Gooding
(1997)
Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype
Journal of Virology, 71
-
D.
Bowen,
Monica
Zen,
Lauren
Holz,
T.
Davis,
G.
McCaughan,
P.
Bertolino
(2004)
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.
The Journal of clinical investigation, 114 5
-
D.
Bowen,
A.
Warren,
T.
Davis,
M.
Hoffmann,
G.
McCaughan,
B.
Groth,
P.
Bertolino
(2002)
Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells.
Gastroenterology, 123 4
-
L.
Carvalho,
J.
Hafalla,
F.
Zavala
(2001)
ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.
Journal of immunological methods, 252 1-2
-
K.
Abe,
T.
Kurata,
Y.
Teramoto,
J.
Shiga,
T.
Shikata
(1993)
Lack of susceptibility of various primates and woodchucks to hepatitis C virus.
Journal of medical primatology, 22 7-8
-
H.
Lerat,
M.
Honda,
M.
Beard,
K.
Loesch,
Jiaren
Sun,
Yan
Yang,
M.
Okuda,
R.
Gosert,
S.
Xiao,
S.
Weinman,
S.
Lemon
(2002)
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.
Gastroenterology, 122 2
-
Martina
Anton,
F.
Graham
(1995)
Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression
Journal of Virology, 69
-
S.
Hayashi,
A.
McMahon
(2002)
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.
Developmental biology, 244 2
-
Y.
Le,
S.
Gagneten,
Donatella
Tombaccini,
B.
Bethke,
B.
Sauer
(1999)
Nuclear targeting determinants of the phage P1 cre DNA recombinase.
Nucleic acids research, 27 24
-
K.
Murphy,
A.
Heimberger,
D.
Loh
(1990)
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.
Science, 250 4988
-
R.
Thimme,
D.
Oldach,
Kyong‐Mi
Chang,
C.
Steiger,
S.
Ray,
F.
Chisari
(2001)
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
The Journal of Experimental Medicine, 194
-
Jiaren
Sun,
Kui
Li,
M.
Shata,
T.
Chan
(2004)
The immunologic basis for hepatitis C infection
Current Opinion in Gastroenterology, 20
-
M.
Herrath,
Sylvia
Guerder,
H.
Lewicki,
R.
Flavell,
M.
Oldstone
(1995)
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes.
Immunity, 3 6
-
T.
Wakita,
C.
Taya,
A.
Katsume,
J.
Kato,
H.
Yonekawa,
Y.
Kanegae,
I.
Saito,
Y.
Hayashi,
M.
Koike,
M.
Kohara
(1998)
Efficient Conditional Transgene Expression in Hepatitis C Virus cDNA Transgenic Mice Mediated by the Cre/loxP System*
The Journal of Biological Chemistry, 273
-
B.
Sauer,
N.
Henderson
(1988)
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
Proceedings of the National Academy of Sciences of the United States of America, 85 14
-
A.
Ohta,
M.
Sekimoto,
Marimo
Sato,
T.
Koda,
S.
Nishimura,
Y.
Iwakura,
K.
Sekikawa,
T.
Nishimura
(2000)
Indispensable Role for TNF-α and IFN-γ at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen1
The Journal of Immunology, 165
-
H.
Isom
(1980)
DNA synthesis in isolated hepatocytes infected with herpesviruses.
Virology, 103 1
-
S.
Diebold,
M.
Montoya,
H.
Unger,
L.
Alexopoulou,
P.
Roy,
L.
Haswell,
A.
Al-Shamkhani,
R.
Flavell,
P.
Borrow,
C.
Sousa
(2003)
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
Nature, 424
-
D.
Nelson,
G.
Lauwers,
J.
Lau,
G.
Davis
(2000)
Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders.
Gastroenterology, 118 4
-
W.
Mehal,
A.
Juedes,
I.
Crispe
(1999)
Selective retention of activated CD8+ T cells by the normal liver.
Journal of immunology, 163 6
-
S.
Zeuzem,
V.
Carreño
(2001)
Interleukin-12 in the treatment of chronic hepatitis B and C.
Antiviral research, 52 2
-
Philippe
Soriano
(1999)
Generalized lacZ expression with the ROSA26 Cre reporter strain
Nature Genetics, 21
-
P.
Bertolino,
M.
Trescol-Biémont,
C.
Rabourdin-Combe
(1998)
Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival
European Journal of Immunology, 28
-
K.
Moriya,
H.
Fujie,
Y.
Shintani,
H.
Yotsuyanagi,
T.
Tsutsumi,
K.
Ishibashi,
Y.
Matsuura,
S.
Kimura,
T.
Miyamura,
K.
Koike
(1998)
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
Nature Medicine, 4
-
H.
Cho,
Tomoko
Hayashi,
Sandip
Datta,
K.
Takabayashi,
J.
Uden,
A.
Horner,
M.
Corr,
E.
Raz
(2002)
IFN-αβ Promote Priming of Antigen-Specific CD8+ and CD4+ T Lymphocytes by Immunostimulatory DNA-Based Vaccines1
The Journal of Immunology, 168
-
R.
Knodell,
K.
Ishak,
W.
Black,
Thomas
Chen,
R.
Craig,
N.
Kaplowitz,
T.
Kiernan,
J.
Wollman
(1981)
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Hepatology, 1
-
A.
Ohta,
M.
Sekimoto,
M.
Sato,
T.
Koda,
S.
Nishimura,
Y.
Iwakura,
K.
Sekikawa,
T.
Nishimura
(2000)
Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen.
Journal of immunology, 165 2
-
R.
Lanford,
Catherine
Bigger,
Suzanne
Bassett,
G.
Klimpel
(2001)
The chimpanzee model of hepatitis C virus infections.
ILAR journal, 42 2
-
J.
Bukh,
Carl
Apgar,
S.
Govindarajan,
S.
Emerson,
R.
Purcell
(2001)
Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a
Journal of Viral Hepatitis, 8
-
Y.
Kanegae,
Gwang
Lee,
Y.
Sato,
Mieko
Tanaka,
Michio
Nakai,
T.
Sakaki,
S.
Sugano,
I.
Saito
(1995)
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase.
Nucleic acids research, 23 19
-
M.
Kantzanou,
M.
Lucas,
E.
Barnes,
H.
Komatsu,
G.
Dusheiko,
S.
Ward,
G.
Harcourt,
P.
Klenerman
(2003)
Viral escape and T cell exhaustion in hepatitis C virus infection analysed using Class I peptide tetramers.
Immunology letters, 85 2
-
(2000)
Fact sheet 164. World Health Organization
-
Brian
Sauer,
N.
Henderson
(1990)
Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.
The New biologist, 2 5
-
Kazuaki
Inoue,
K.
Sekiyama,
M.
Yamada,
Tsunamasa
Watanabe,
H.
Yasuda,
M.
Yoshiba
(2003)
Combined interferon α2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial
Journal of Gastroenterology, 38
-
Jennifer
Lund,
A.
Sato,
S.
Akira,
R.
Medzhitov,
A.
Iwasaki
(2003)
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
The Journal of Experimental Medicine, 198
-
R.
Thimme,
J.
Bukh,
H.
Spangenberg,
S.
Wieland,
J.
Pemberton,
C.
Steiger,
S.
Govindarajan,
R.
Purcell,
F.
Chisari
(2002)
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Proceedings of the National Academy of Sciences of the United States of America, 99
-
Guisheng
Zhang,
Young
Song,
Dexi
Liu
(2000)
Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure
Gene Therapy, 7
-
Jiaren
Sun,
F.
Bodola,
Xuegong
Fan,
Habib
Irshad,
L.
Soong,
S.
Lemon,
T.
Chan
(2001)
Hepatitis C Virus Core and Envelope Proteins Do Not Suppress the Host's Ability To Clear a Hepatic Viral Infection
Journal of Virology, 75
-
K.
Klugewitz,
F.
Blumenthal-Barby,
A.
Schrage,
P.
Knolle,
A.
Hamann,
I.
Crispe
(2002)
Immunomodulatory Effects of the Liver: Deletion of Activated CD4+ Effector Cells and Suppression of IFN-γ-Producing Cells After Intravenous Protein Immunization1
The Journal of Immunology, 169
-
J.
Savulescu
(2001)
Harm, ethics committees and the gene therapy death
Journal of Medical Ethics, 27
-
M.
Shata,
D.
Anthony,
N.
Carlson,
L.
Andrus,
B.
Brotman,
N.
Tricoche,
P.
McCormack,
A.
Prince
(2002)
Characterization of the immune response against hepatitis C infection in recovered, and chronically infected chimpanzees
Journal of Viral Hepatitis, 9
-
Kazuaki
Inoue,
K.
Sekiyama,
M.
Yamada,
Tsunamasa
Watanabe,
H.
Yasuda,
M.
Yoshiba
(2003)
Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial.
Journal of gastroenterology, 38 6
-
W.
Mehal,
F.
Azzaroli,
I.
Crispe,
Howard
Hughes,
P.
Fellowship
(2001)
Antigen Presentation by Liver Cells Controls Intrahepatic T Cell Trapping, Whereas Bone Marrow-Derived Cells Preferentially Promote Intrahepatic T Cell Apoptosis1
The Journal of Immunology, 167
-
Feng
Liu,
Y.
Song,
Dexi
Liu
(1999)
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
Gene Therapy, 6
-
(2000)
Interleukin 10738 SUN ET AL
-
K.
Mochizuki,
N.
Hayashi,
K.
Katayama,
N.
Hiramatsu,
T.
Kanto,
E.
Mita,
T.
Tatsumi,
N.
Kuzushita,
A.
Kasahara,
H.
Fusamoto,
T.
Yokochi,
T.
Kamada
(1997)
B7/BB‐1 expression and hepatitis activity in liver tissues of patients with chronic hepatitis C
Hepatology, 25
-
I.
Crispe
(2003)
Hepatic T cells and liver tolerance
Nature Reviews Immunology, 3
-
N.
Gruener,
F.
Lechner,
M.
Jung,
H.
Diepolder,
T.
Gerlach,
G.
Lauer,
B.
Walker,
J.
Sullivan,
R.
Phillips,
G.
Pape,
P.
Klenerman
(2001)
Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus
Journal of Virology, 75
-
Jiaren
Sun,
Bernadette
Dirden-Kramer,
Komei
Ito,
Peter
Ernst,
N.
Houten
(1999)
Antigen-specific T cell activation and proliferation during oral tolerance induction.
Journal of immunology, 162 10
-
N.
Shoukry,
A.
Grakoui,
M.
Houghton,
D.
Chien,
J.
Ghrayeb,
K.
Reimann,
C.
Walker
(2003)
Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
The Journal of Experimental Medicine, 197
-
A.
Su,
J.
Pezacki,
L.
Wodicka,
A.
Brideau,
L.
Supeková,
R.
Thimme,
S.
Wieland,
J.
Bukh,
R.
Purcell,
P.
Schultz,
F.
Chisari
(2002)
Genomic analysis of the host response to hepatitis C virus infection
Proceedings of the National Academy of Sciences of the United States of America, 99
-
H.
Cho,
Tomoko
Hayashi,
Sandip
Datta,
K.
Takabayashi,
J.
Uden,
A.
Horner,
M.
Corr,
E.
Raz
(2002)
IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines.
Journal of immunology, 168 10
-
D.
Jo,
Abudi
Nashabi,
Christie
Doxsee,
Qing
Lin,
D.
Unutmaz,
Jin
Chen,
H.
Ruley
(2001)
Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase
Nature Biotechnology, 19
-
B.
Sauer,
N.
Henderson
(1989)
Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome.
Nucleic acids research, 17 1
-
Sylvia
Guerder,
D.
Picarella,
Peter
LINSLEYt,
R.
Flavell
(1994)
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America, 91 11