Abstract

Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://mmbr.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ MICROBIOLOGICAL REVIEWS, Dec. 1982, p. 384-425 0146-0749/82/040384-42$02.00/0 Copyright © 1982, American Society for Microbiology Vol. 46, No.4 LEONARD C. NORKIN Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003 INTRODUCTION ................................................................ Variety of Host Responses to Virus Infection ....................................... The Papovaviruses . ............................................................ Importance of In Vitro Model Systems ............................................ Scope of the Review . ........................................................... GENERAL CHARACTERISTICS OF PERSISTENT INFECTIONS IN VITRO .......... PAPOVAVIRAL PERSISTENT INFECTIONS: IN VITRO AND IN VIVO .............. Simian Virus 40 ............................................................... 385 385 Discovery .................................................................. Interactions with cultured cells ................................................. Establishment and maintenance of persistent infections: importance and modes of action of resistant cells and viral variants ...... ....................... Latent infection: state of the viral genomes and reactivation of the productive infection . . Induction and rearrangement of integrated viral genomes ...... ................... Polyoma Virus ................................................................ Discovery ................................................................. Interactions with cultured cells ................................................. Persistent infection: roles of resistant cells and viral autointerference ................ Integrated and episomal viral genomes .......................................... Induction and rearrangement of integrated viral genomes: role of the viral T antigen