Molecular basis of transmembrane signal transduction in Dictyostelium discoideum.
Abstract
Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://mmbr.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ MICROBIOLOGICAL REVIEWS, Dec. 1987, p. 396-418 0146-0749/87/040396-23$02.00/0 Copyright © 1987, American Society for Microbiology Vol. 51, No. 4 Molecular Basis of Transmembrane Signal Transduction in Dictyostelium discoideum PIM M. W. JANSSENS* AND PETER J. M. VAN HAASTERT Cell Biology and Genetics Unit, Zoological Laboratory, University of Leiden, 2311 GP Leiden, The Netherlands INTRODUCTION ................................................................. PHYSIOLOGY OF SIGNAL TRANSDUCTION IN D. .............................................397 DISCOIDEUM cAMP RECEPTORS IN D. DISCOIDEUM ................................................................. Introduction ............................................................... Ligand Specificity and Activation Mechanism of the Receptor ......................................................399 Kinetic Properties of the cAMP Receptor ................................................................ 400 Coupling of Receptor Forms to G-Protein and Adenylate and Guanylate Cyclase .............................401 Isolation of the Receptor ............................................................... 402 Agents That Modulate cAMP Binding ................................................................ 403 FOLIC ACID RECEPTORS ................................................................ 404 ADENYLATE CYCLASE ................................................................405 Downloaded from http://mmbr.asm.org/ on December 24, 2011 by deepdyve Activity ............................................................... 405 Activity ............................................................... 405 GUANYLATE CYCLASE AND THE INOSITOL PHOSPHATE PATHWAY ....................................406 Basal Stimulated DESENSITIZATION TO cAMP ................................................................ Alterations in Binding Properties ................................................................ Covalent Modification of Receptors ............................................................... 408 COMPARISON WITH OTHER EUCARYOTIC MICROBES ........................................................408 PROSPECTS ................................................................