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Effects of Length and Location on the Cellular Response to Double-Stranded RNA

Effects of Length and Location on the Cellular Response to Double-Stranded RNA Effects of Length and Location on the Cellular Response to Double-Stranded RNA Qiaoqiao Wang and Gordon G. Carmichael * Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut SUMMARY Since double-stranded RNA (dsRNA) has not until recently generally been thought to be deliberately expressed in cells, it has commonly been assumed that the major source of cellular dsRNA is viral infections. In this view, the cellular responses to dsRNA would be natural and perhaps ancient antiviral responses. While the cell may certainly react to some dsRNAs as an antiviral response, this does not represent the only response or even, perhaps, the major one. A number of recent observations have pointed to the possibility that dsRNA molecules are not seen only as evidence of viral infection or recognized for degradation because they cannot be translated. In some instances they may also play important roles in normal cell growth and function. The purpose of this review is to outline our current understanding of the fate of dsRNA in cells, with a focus on the apparent fact that their fates and functions appear to depend critically not only on where in the cell dsRNA molecules are found, but also on how long they are and perhaps on how abundant they are. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Microbiology and Molecular Biology Reviews American Society For Microbiology

Effects of Length and Location on the Cellular Response to Double-Stranded RNA

Effects of Length and Location on the Cellular Response to Double-Stranded RNA

Microbiology and Molecular Biology Reviews , Volume 68 (3): 432 – Sep 1, 2004

Abstract

Effects of Length and Location on the Cellular Response to Double-Stranded RNA Qiaoqiao Wang and Gordon G. Carmichael * Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut SUMMARY Since double-stranded RNA (dsRNA) has not until recently generally been thought to be deliberately expressed in cells, it has commonly been assumed that the major source of cellular dsRNA is viral infections. In this view, the cellular responses to dsRNA would be natural and perhaps ancient antiviral responses. While the cell may certainly react to some dsRNAs as an antiviral response, this does not represent the only response or even, perhaps, the major one. A number of recent observations have pointed to the possibility that dsRNA molecules are not seen only as evidence of viral infection or recognized for degradation because they cannot be translated. In some instances they may also play important roles in normal cell growth and function. The purpose of this review is to outline our current understanding of the fate of dsRNA in cells, with a focus on the apparent fact that their fates and functions appear to depend critically not only on where in the cell dsRNA molecules are found, but also on how long they are and perhaps on how abundant they are.

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Publisher
American Society For Microbiology
Copyright
Copyright © 2004 by the American society for Microbiology.
ISSN
1092-2172
eISSN
1098-5557
DOI
10.1128/MMBR.68.3.432-452.2004
pmid
15353564
Publisher site
See Article on Publisher Site

Abstract

Effects of Length and Location on the Cellular Response to Double-Stranded RNA Qiaoqiao Wang and Gordon G. Carmichael * Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut SUMMARY Since double-stranded RNA (dsRNA) has not until recently generally been thought to be deliberately expressed in cells, it has commonly been assumed that the major source of cellular dsRNA is viral infections. In this view, the cellular responses to dsRNA would be natural and perhaps ancient antiviral responses. While the cell may certainly react to some dsRNAs as an antiviral response, this does not represent the only response or even, perhaps, the major one. A number of recent observations have pointed to the possibility that dsRNA molecules are not seen only as evidence of viral infection or recognized for degradation because they cannot be translated. In some instances they may also play important roles in normal cell growth and function. The purpose of this review is to outline our current understanding of the fate of dsRNA in cells, with a focus on the apparent fact that their fates and functions appear to depend critically not only on where in the cell dsRNA molecules are found, but also on how long they are and perhaps on how abundant they are.

Journal

Microbiology and Molecular Biology ReviewsAmerican Society For Microbiology

Published: Sep 1, 2004

There are no references for this article.