Abstract

CONTENT ALERTS Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://jb.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ LEO G. NUTINI, SR. THOMAS AQUIN KELLY, AND SR. MARGARET ANN McDOWELL Laboratories of the Institutum Divi Thomae, Cincinnati, Ohio, and its associated unit at St. Mary of the Springs College, Columbus, Ohio Received for publication January 7, 1946 For some time past, reports dealing with the effect of protein-free alcoholic extracts of various animal tissues on the growth of certain bacteria in vitro and in vivo have come from these laboratories (Nutini and Kreke, 1942; Nutini, Kreke, and Schroeder, 1945; Nutini and Lynch, 1945). The effectiveness of such extracts suggested further research using extracts of specific bacteria instead of the animal tissues. These bacterial extracts, by the nature of their preparation, differ from the bacterial filtrates investigated by other workers. Observations on the manner in which bacterial filtrates affect the growth of microorganisms have been made since the time of Pasteur. Within relatively recent years research concerned with bacteriostatic agents, initiated by Dubos (1939), has been carried on by such workers as Hettche and Weber