Antimalarial agents: mechanisms of action.
Abstract
Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://aac.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 1988, p. 793-798 0066-4804/88/060793-06$02.00/0 Copyright © 1988, American Society for Microbiology Vol. 32, No. 6 PAUL H. SCHLESINGER,' DONALD J. KROGSTAD,2"3* AND BARBARA L. HERWALDT2 Departments of Medicine2 and Pathology,3 Washington University School of Medicine, 660 South Euclid Avenue, and Department of Biomedical Research, Washington University School of Dental Medicine,' St. Louis, Missouri 63110 INTRODUCTION Global impact of malaria. The data available suggest that there are 200 million to 300 million cases of malaria, with more than 2 million deaths, each year (70). Most deaths result from Plasmodium falciparum infection in Africa and are among children less than 5 years of age. The numbers of malaria cases and deaths dwarf those of virtually all other infectious diseases, including human immunodeficiency virus infection. Plasmodia that infect humans. Four species of malaria parasites infect humans: P. falciparum, P. vivax, P. ovale, and P. malariae. Of these, only P. falciparum poses a significant risk of death in the nonimmune patient, because of its ability to invade