Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Working Memory Control in Patients With Schizophrenia: A PET Study During a Random Number Generation Task

Working Memory Control in Patients With Schizophrenia: A PET Study During a Random Number... OBJECTIVE: The authors’ goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia. METHOD: Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed. RESULTS: The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects. CONCLUSIONS: These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Psychiatry American Psychiatric Publishing, Inc (Journal)

Working Memory Control in Patients With Schizophrenia: A PET Study During a Random Number Generation Task

Working Memory Control in Patients With Schizophrenia: A PET Study During a Random Number Generation Task

American Journal of Psychiatry , Volume 157 (9): 1517 – Sep 1, 2000

Abstract

OBJECTIVE: The authors’ goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia. METHOD: Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed. RESULTS: The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects. CONCLUSIONS: These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia.

Loading next page...
 
/lp/american-psychiatric-publishing-inc-journal/working-memory-control-in-patients-with-schizophrenia-a-pet-study-1AGepusrXv

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © 2000 American Psychiatric Association. All rights reserved.
ISSN
0002-953X
DOI
10.1176/appi.ajp.157.9.1517
pmid
10964875
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVE: The authors’ goal was to investigate brain regions involved in the deficiency of working memory control processes in patients with schizophrenia. METHOD: Regional cerebral blood flow was measured with positron emission tomography in eight men with stabilized schizophrenia and eight healthy men while they were performing a graded random number generation task. Twelve scans were made for each subject. Covariations between randomness of responses and regional activation were analyzed. RESULTS: The pattern of covariation between randomness of responses and activation in the anterior cingulate and superior parietal regions differed between patients and healthy subjects. CONCLUSIONS: These results suggest a cinguloparietal dysfunction underlying the impairment of working memory control processes during a random number generation task in patients with schizophrenia.

Journal

American Journal of PsychiatryAmerican Psychiatric Publishing, Inc (Journal)

Published: Sep 1, 2000

There are no references for this article.