Abstract

of in ResearchM.D. is by their aDepression:H.MARSHALL,#{149} The has toricalKuhn,efficacy nowof the beentricyclic wellBrodie.’antidepressants and documented disipramine their hisby had trials, of acdirect in ondevelopment By 1968, imipraminesmoking6.broad research avenues anti-anxiety drug data perly pounds. To must search.available so obtained of and such in suchare clear; will prothese volumebeen compared usually in regard tion, double others previous and the side blindin a number of clinical to effectiveness, onset effects. comparisons based Comparative In some studies, were his made; opinionour theknowledge duplicity for use ofcomof reto thereduce also beantidepressant Imaginativeinvestigations, searcheda freshinvestigator experience. hampered is notdepression populationsevaluation groups and used. com-is somewhat differ, dosage in Inbecause patient always comparable drugs drugs were weresome studies additional general, when the two efficacy adversehad if not beginningclinical trial will well as stimulating resultsbelieve,provide needed new physician interest Thedata as in the trial, weobtained.is suchpared, overall lent and thetype. Desipramineof the effectsa slight in results oftwo was equivawere similar inadvantage two therapy. weeks In in or an Tra-approach. STUDY therapeutic in patients practice. effects seen TheCOLLABORATIVE a study was private of theof activityafter of theof routinely1969,planned psychiatricextensive ness ganza studies cacy andeffective1969), 92 effiindiand that sameob-Smith,patients patientwere basis,be clearlymanageable depressedof aon andHarrison4 28