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The availability of D-phenylalanine and DL-phenylalanine

The availability of D-phenylalanine and DL-phenylalanine nonsuppressors.had ACTH levels less than IS pg/ml; 17 of the 20 had ACTH levels less than 10 pg/ml and three had levels between 10 and 15 pg/ml. All 13 patients who were suppressors on the DST also had ACTH levels of less than IS pg/ml; I I had levels of less than 10 pg/mI and two had levels between 10 and 15 pg/ml. Of the nonsuppressors, two had levels less than 10 pg/mI, two had levels between 10 and 15 pg/mI, and five had levels greater than IS pg/mI. There was a highly significant difference between the ACTH values of the psychiatric patients who were suppressors and those who were nonsuppressors (6.5±2.3 and 19.9±10.9 pg/ml, Mann-Whitney U test, one-tailed, p<.OO2). The post-DST plasma cortisol and ACTH levels were also significantly correlated (r’ .69, N=22, p<.OOl). Although the blood samples were drawn only at 4:00 p.m. and, due to the short half-life of ACTH, preceding ACTH level peaks causing a cortisol elevation at 4:00 p.m. may have been missed, these results support a close link between ACTH and cortisol secretion following administration of dexamethasone in healthy probands and psychiatric inpatients. Our results, therefore, support those of Reus et al. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Psychiatry American Psychiatric Publishing, Inc (Journal)

The availability of D-phenylalanine and DL-phenylalanine

The availability of D-phenylalanine and DL-phenylalanine

American Journal of Psychiatry , Volume 142 (2) – Feb 1, 1985

Abstract

nonsuppressors.had ACTH levels less than IS pg/ml; 17 of the 20 had ACTH levels less than 10 pg/ml and three had levels between 10 and 15 pg/ml. All 13 patients who were suppressors on the DST also had ACTH levels of less than IS pg/ml; I I had levels of less than 10 pg/mI and two had levels between 10 and 15 pg/ml. Of the nonsuppressors, two had levels less than 10 pg/mI, two had levels between 10 and 15 pg/mI, and five had levels greater than IS pg/mI. There was a highly significant difference between the ACTH values of the psychiatric patients who were suppressors and those who were nonsuppressors (6.5±2.3 and 19.9±10.9 pg/ml, Mann-Whitney U test, one-tailed, p<.OO2). The post-DST plasma cortisol and ACTH levels were also significantly correlated (r’ .69, N=22, p<.OOl). Although the blood samples were drawn only at 4:00 p.m. and, due to the short half-life of ACTH, preceding ACTH level peaks causing a cortisol elevation at 4:00 p.m. may have been missed, these results support a close link between ACTH and cortisol secretion following administration of dexamethasone in healthy probands and psychiatric inpatients. Our results, therefore, support those of Reus et al.

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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © American Psychiatric Association. All rights reserved
ISSN
0002-953X
Publisher site
See Article on Publisher Site

Abstract

nonsuppressors.had ACTH levels less than IS pg/ml; 17 of the 20 had ACTH levels less than 10 pg/ml and three had levels between 10 and 15 pg/ml. All 13 patients who were suppressors on the DST also had ACTH levels of less than IS pg/ml; I I had levels of less than 10 pg/mI and two had levels between 10 and 15 pg/ml. Of the nonsuppressors, two had levels less than 10 pg/mI, two had levels between 10 and 15 pg/mI, and five had levels greater than IS pg/mI. There was a highly significant difference between the ACTH values of the psychiatric patients who were suppressors and those who were nonsuppressors (6.5±2.3 and 19.9±10.9 pg/ml, Mann-Whitney U test, one-tailed, p<.OO2). The post-DST plasma cortisol and ACTH levels were also significantly correlated (r’ .69, N=22, p<.OOl). Although the blood samples were drawn only at 4:00 p.m. and, due to the short half-life of ACTH, preceding ACTH level peaks causing a cortisol elevation at 4:00 p.m. may have been missed, these results support a close link between ACTH and cortisol secretion following administration of dexamethasone in healthy probands and psychiatric inpatients. Our results, therefore, support those of Reus et al.

Journal

American Journal of PsychiatryAmerican Psychiatric Publishing, Inc (Journal)

Published: Feb 1, 1985

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