Abstract

[AprilEDEMA THERAPYM.D.’R. HINE,The effect or ofedema ofoccasionally and non-specificas a side-type.is of a mildvital signs emergencyremained treatmentnormal and was given.transient acuteCronqvist, underet a!.treatment experienced( i),edema intwo casespatients one ofangioneurotic somechlorpromazine, respiratorydistress. The present report describes a single case of severe angioneurotic edema occurring during chlorpromazine administration and responding to antihistamine and ACTH therapy. The patient, a 34-year-old white female, had been psychotic for 9 years, with a diagnosis of schizophrenia. was ofOn prescribedJuly for22,1957,chiorpromazine time at a dosemg.t.i.d.t.i.d., 26 andof toxicincreased continuedsymptoms.to atthat Duringthe patient became slightly more attentive and responsive to the ward personnel and was not assaultive. Routine blood counts were within normal limits throughout the period described by this report. She was not receiving medication other than chlorpromazine. On August 13, a slight puffiness of the lips was noticed. By the following day moderatetreatment edema apparent. of lips, cheeks and eyelids was was readily Chlorpromazine discontinued50 thatmg. day,q 4 h by Augustmouth.14,placed Byevening ofOn the morning of August i, the patient was found to be in great distress. The severe facial edema had caused extrusion of the contents of the sebaceous glands. The patient’s eyes were completely obscured and the tongue and mucous membranes of