Priapism Following Olanzapine Administration in a Patient With Multiple Sclerosis

Priapism Following Olanzapine Administration in a Patient With Multiple Sclerosis Received August 20, 1997; accepted September 4, 1997. From the Avery D. Weisman Psychiatry Consultation Service, and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Address reprint requests to Dr. Heckers, Department of Psychiatry, Massachusetts General Hospital, Warren 605, Fruit Street, Boston, MA 02214. e-mail: heckers{at}psych.mgh.harvard.edu Key Words: Case Report • Priapism • Olanzapine • Multiple Sclerosis Priapism is the pathologically prolonged painful erection of the penis. It is a urological emergency that requires immediate treatment to prevent complications, for example, difficulty with urination, urinary retention, impotence, cavernosa fibrosis, and gangrene. Roughly from 40% to 50% of patients who develop priapism become impotent, even after surgical treatment.1 The cause of priapism remains unclear in 50% of cases. Known causes of priapism include blood dyscrasias (sickle cell disease, leukemia, nephrotic syndrome, multiple myeloma, hyperviscosity states); solid tumors; trauma; spinal-cord injuries; and stroke. Drug-induced priapism accounts for 15% to 41% of all cases,l most often associated with two classes of drugs, neuroleptics and antihypertensives. Neuroleptic-induced priapism has been reported for phenothiazines, butyrophenones, risperidone, and clozapine.2 Here we report the first case of priapism associated with the use of olanzapine. Case ReportMr. A., a 68-year old man http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychosomatics American Psychiatric Publishing, Inc (Journal)

Priapism Following Olanzapine Administration in a Patient With Multiple Sclerosis

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Priapism Following Olanzapine Administration in a Patient With Multiple Sclerosis

Psychosomatics, Volume 39 (3): 288 – Jun 1, 1998

Abstract

Received August 20, 1997; accepted September 4, 1997. From the Avery D. Weisman Psychiatry Consultation Service, and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Address reprint requests to Dr. Heckers, Department of Psychiatry, Massachusetts General Hospital, Warren 605, Fruit Street, Boston, MA 02214. e-mail: heckers{at}psych.mgh.harvard.edu Key Words: Case Report • Priapism • Olanzapine • Multiple Sclerosis Priapism is the pathologically prolonged painful erection of the penis. It is a urological emergency that requires immediate treatment to prevent complications, for example, difficulty with urination, urinary retention, impotence, cavernosa fibrosis, and gangrene. Roughly from 40% to 50% of patients who develop priapism become impotent, even after surgical treatment.1 The cause of priapism remains unclear in 50% of cases. Known causes of priapism include blood dyscrasias (sickle cell disease, leukemia, nephrotic syndrome, multiple myeloma, hyperviscosity states); solid tumors; trauma; spinal-cord injuries; and stroke. Drug-induced priapism accounts for 15% to 41% of all cases,l most often associated with two classes of drugs, neuroleptics and antihypertensives. Neuroleptic-induced priapism has been reported for phenothiazines, butyrophenones, risperidone, and clozapine.2 Here we report the first case of priapism associated with the use of olanzapine. Case ReportMr. A., a 68-year old man
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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © 1998 Academy of Psychosomatic Medicine. All rights reserved.
ISSN
0033-3182
Publisher site
See Article on Publisher Site

Abstract

Received August 20, 1997; accepted September 4, 1997. From the Avery D. Weisman Psychiatry Consultation Service, and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Address reprint requests to Dr. Heckers, Department of Psychiatry, Massachusetts General Hospital, Warren 605, Fruit Street, Boston, MA 02214. e-mail: heckers{at}psych.mgh.harvard.edu Key Words: Case Report • Priapism • Olanzapine • Multiple Sclerosis Priapism is the pathologically prolonged painful erection of the penis. It is a urological emergency that requires immediate treatment to prevent complications, for example, difficulty with urination, urinary retention, impotence, cavernosa fibrosis, and gangrene. Roughly from 40% to 50% of patients who develop priapism become impotent, even after surgical treatment.1 The cause of priapism remains unclear in 50% of cases. Known causes of priapism include blood dyscrasias (sickle cell disease, leukemia, nephrotic syndrome, multiple myeloma, hyperviscosity states); solid tumors; trauma; spinal-cord injuries; and stroke. Drug-induced priapism accounts for 15% to 41% of all cases,l most often associated with two classes of drugs, neuroleptics and antihypertensives. Neuroleptic-induced priapism has been reported for phenothiazines, butyrophenones, risperidone, and clozapine.2 Here we report the first case of priapism associated with the use of olanzapine. Case ReportMr. A., a 68-year old man

Journal

PsychosomaticsAmerican Psychiatric Publishing, Inc (Journal)

Published: Jun 1, 1998

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