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Phenothiazines and Diabetes in Hospitalized Women

Phenothiazines and Diabetes in Hospitalized Women ERNST THONNARD-NEUMANN M.D. 1 1 Medical officer, Saint Elizabeths Hospital, Washington, D. C. 20032 Between 1955 and 1966 the prevalence of diabetes among hospitalized psychotic women patients rose from 4.2 to 17.2 percent. The increase followed the introduction of chlorpromazine therapy in 1954. About every fourth patient who had been treated for one year or longer with more than 100 mg. daily of chlorpromazine or corresponding doses of another psychoactive pheno thiazine developed hyperglycemia and glycosuria. The disturbance resembled adult-onset diabetes, but there were fewer complications. In 25 percent of the patients remissions occurred either after withdrawal of the drug or reduction in dosage. Obese patients over 50 years old and those with a family history of diabetes were more often affected. Patients with paranoid schizophrenic reaction developed diabetes after phenothiazine therapy relatively more frequently than did those with other forms of schizophrenic reactions or with nonschizophrenic psychiatric diagnoses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Psychiatry American Psychiatric Publishing, Inc (Journal)

Phenothiazines and Diabetes in Hospitalized Women

American Journal of Psychiatry , Volume 124 (7): 978 – Jan 1, 1968

Phenothiazines and Diabetes in Hospitalized Women

American Journal of Psychiatry , Volume 124 (7): 978 – Jan 1, 1968

Abstract

ERNST THONNARD-NEUMANN M.D. 1 1 Medical officer, Saint Elizabeths Hospital, Washington, D. C. 20032 Between 1955 and 1966 the prevalence of diabetes among hospitalized psychotic women patients rose from 4.2 to 17.2 percent. The increase followed the introduction of chlorpromazine therapy in 1954. About every fourth patient who had been treated for one year or longer with more than 100 mg. daily of chlorpromazine or corresponding doses of another psychoactive pheno thiazine developed hyperglycemia and glycosuria. The disturbance resembled adult-onset diabetes, but there were fewer complications. In 25 percent of the patients remissions occurred either after withdrawal of the drug or reduction in dosage. Obese patients over 50 years old and those with a family history of diabetes were more often affected. Patients with paranoid schizophrenic reaction developed diabetes after phenothiazine therapy relatively more frequently than did those with other forms of schizophrenic reactions or with nonschizophrenic psychiatric diagnoses.

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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © 1968 American Psychiatric Association. All rights reserved.
ISSN
0002-953X
DOI
10.1176/appi.ajp.124.7.978
Publisher site
See Article on Publisher Site

Abstract

ERNST THONNARD-NEUMANN M.D. 1 1 Medical officer, Saint Elizabeths Hospital, Washington, D. C. 20032 Between 1955 and 1966 the prevalence of diabetes among hospitalized psychotic women patients rose from 4.2 to 17.2 percent. The increase followed the introduction of chlorpromazine therapy in 1954. About every fourth patient who had been treated for one year or longer with more than 100 mg. daily of chlorpromazine or corresponding doses of another psychoactive pheno thiazine developed hyperglycemia and glycosuria. The disturbance resembled adult-onset diabetes, but there were fewer complications. In 25 percent of the patients remissions occurred either after withdrawal of the drug or reduction in dosage. Obese patients over 50 years old and those with a family history of diabetes were more often affected. Patients with paranoid schizophrenic reaction developed diabetes after phenothiazine therapy relatively more frequently than did those with other forms of schizophrenic reactions or with nonschizophrenic psychiatric diagnoses.

Journal

American Journal of PsychiatryAmerican Psychiatric Publishing, Inc (Journal)

Published: Jan 1, 1968

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