IMIPRAMINE HYDROCHLORIDE (TOFR NIL) AND ENURESIS
Abstract
day. In another patient some difficulty in voiding took place. All these patients had moderate prostatic enlargement. On one of them a transurethral resection was done; the other patients either had the dosage lowered, or a Foley catheter was inserted to ameliorate the symptom. It is not possible to fully implicate the imipramine, as, of course, many of these patients were receiving other medication which have effects on the autonomic nerv-(suchHowever,and in one case, probanthine). it is well worth while to bearthis in mind complaint ofin voidinga middle-agedon imipramine. In summary,to be a of depression, but its action is unpredictable and apparently is not highly effective in the more severe cases.useful drug in the treatmentR. E. G. MAcLEAN,(TOFRANIL)M.B., B.S., D.P.M.âIn the course of studying the application of imipram.ine hydrochloride (Tofranil) to depressive states encountered in adults attending the Observatory Clinic, a mixed adult outpatient and child guidance clinic under the Victorian Mental Hygiene Authority, the senior psychologist (Mr. Hugh Esson) suggested that this drug might be of use in the management of enuresis in children. It was tried, and, possibly as a result of the difficulty in initiating micturition which is reported as a side-effect of the drug