RNA topology remolds electrostatic stabilization of viruses

RNA topology remolds electrostatic stabilization of viruses Simple RNA viruses efficiently encapsulate their genome into a nano-sized protein shell: the capsid. Spontaneous coassembly of the genome and the capsid proteins is driven predominantly by electrostatic interactions between the negatively charged RNA and the positively charged inner capsid wall. Using field theoretic formulation we show that the inherently branched RNA secondary structure allows viruses to maximize the amount of encapsulated genome and make assembly more efficient, allowing viral RNAs to out-compete cellular RNAs during replication in infected host cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physical Review E American Physical Society (APS)

RNA topology remolds electrostatic stabilization of viruses

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Publisher
American Physical Society (APS)
Copyright
©2014 American Physical Society
Subject
ARTICLES; Biological Physics
ISSN
1539-3755
eISSN
1550-2376
D.O.I.
10.1103/PhysRevE.89.032707
Publisher site
See Article on Publisher Site

Abstract

Simple RNA viruses efficiently encapsulate their genome into a nano-sized protein shell: the capsid. Spontaneous coassembly of the genome and the capsid proteins is driven predominantly by electrostatic interactions between the negatively charged RNA and the positively charged inner capsid wall. Using field theoretic formulation we show that the inherently branched RNA secondary structure allows viruses to maximize the amount of encapsulated genome and make assembly more efficient, allowing viral RNAs to out-compete cellular RNAs during replication in infected host cells.

Journal

Physical Review EAmerican Physical Society (APS)

Published: Mar 14, 2014

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