Abstract McNair1 in 1917 recommended the use of iron salts in the treatment and prevention of poison ivy dermatitis. He found a rational explanation of its apparent good effect in that the toxic principle of rhus is precipitated and perhaps denatured when it comes in contact with iron. This method of treatment was first used by White in 1873;2 therefore, it seems to have been in use for many years previous to McNair's report. Pusey3 in 1930 was the first to report a case of brown stains in the skin from wet dressings of a solution of ferrous sulfate. The stains on his patient's skin remained for years. Traub and Tenner4 reported 2 cases of this type of metallic pigmentation following the use of solutions of ferrous sulfate and ferric chloride and referred to 4 additional cases occurring in the service of Dr. George M. MacKee. Sutton References 1. McNair, J. B.: A Contribution to the Chemotherapy of Rhus Dermatitis . Arch. Dermat. & Syph. 3:802-808 ( (June) ) 1921 2. Rhus Dermatitis , Chicago, University of Chicago Press, 1923, p. 179. 3. White, J. C.: On the Action of Rhus Venenata and Rhus Toxicodendron upon the Human Skin , New York M. J. 17:225-249, 1873. 4. Pusey, W. A.: Brown Stains in Skin from Wet Dressings of a Solution of Copperas , J. A. M. A. 94:207 ( (Jan. 18) ) 1930. 5. Traub, E. F., and Tenner, J. S.: Permanent Pigmentation Following Application of Iron Salts , J. A. M. A. 106:1711-1712 ( (May 16) ) 1936. 6. Sutton, R. L., Jr.: Pigmentation of the Skin Due to Iron (Copperas) Applied Locally , J. A. M. A. 108:112-113 ( (Jan. 9) ) 1937. 7. Foerster, H. A.: The Treatment of Poison Ivy , J. Oklahoma M. A. 31: 245-247 ( (July) ) 1938. 8. Reyner, C. E.: Pigmentation Following the Use of Iron Salts , Arch. Dermat. & Syph. 40:380-381 ( (Sept.) ) 1939. 9. Iron Chloride Solution Is Good Treatment for Poison Ivy , Hygeia 10:767 ( (Aug.) ) 1932. 10. McNair, J. B.: Poison Ivy , Leaflet 12, Botany, Field Museum of Natural History, Chicago, 1926. 11. Ivy and Sumac Poisoning , Pub. Health Rep. , 1940, (supp. 161) . 12. Ivy Poisoning and Lobinol, Queries and Minor Notes , J. A. M. A. 97: 341 ( (Aug. 1) ) 1931. 13. Dermatitis Venenata, Queries and Minor Notes , J. A. M. A. 102: 1517 ( (May 5) ) 1934. 14. Byram, A. T.: Poison Ivy Control , Canad. Pub. Health J. 22:291-292 ( (June) ) 1931. 15. McNair, J. B.: A Dependable Remedy for the Poison Ivy Group , Am. Biol. Teacher 2:100-101, 1940. 16. Manlove, W. R., Jr.: Ivy Poisoning , U. S. Nav. M. Bull. 33:183-187 ( (April) ) 1935. 17. The significance of this article lies chiefly in the spectrographic and microincineration studies, which were done by Dr. Ross C. MacCardle, research associate to the Dermatologic Department of the Barnard Free Skin and Cancer Hospital.
Archives of Dermatology and Syphilology – American Medical Association
Published: Apr 1, 1941