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XANTHOMA DISSEMINATUM: An Unusual Form with Extension of Xanthomatous Changes into Muscle

XANTHOMA DISSEMINATUM: An Unusual Form with Extension of Xanthomatous Changes into Muscle Abstract XANTHOMA disseminatum is an entity that is infrequently encountered. It represents a systemic disorder involving the reticuloendothelial system, particularly the reticulum cells and the histiocytes. It differs in the main from xanthoma tuberosum in that the blood serum cholesterol is normal or low1 and the lesions are more commonly found on the flexural surfaces of the skin. In addition to skin involvement, many other organs and tissues have been found with xanthomatous changes. Lesions have been demonstrated on the mucosal surface of the mouth, epiglottis, and larynx, on the cornea and sclera,2 in the pleura, lungs, pituitary gland, and the tuber cinereum,3 in bones, spinal cord, lymph glands, and spleen,4 in the brain,5 in the liver,6 and on the serous surfaces of the pericardium and peritoneum, the walls of the esophagus, stomach, and intestinal mucosa, as well as in glands (thymus, pancreas, and References 1. Thannhauser, S. J., and Magendantz, H.: The Different Clinical Groups of Xanthomatous Diseases: A Clinical Physiological Study of 22 Cases , Ann. Int. Med. 11:1662, 1938.Crossref 2. Pusey, W. A., and Johnstone, O. P.: A Case of Xanthoma Diabeticorum and Lipoma Multiplex, and a Case of Xanthoma Approaching the Diabetic Type with Diabetes Insipidus , J. Cutan. Dis. 26:552, 1908. 3. Turner, A. L.; Davidson, J., and White, A. C.: Xanthomatosis: Some Aspects of Its Blood Chemistry and Pathology , Edinburgh M. J. 32:153, 1925. 4. Horsfall, F. L., Jr., and Smith, W. R.: Schüller-Christian Syndrome: Lipoid Granulomatosis: Defects in the Bones, Exophthalmos and Diabetes Insipidus , Quart. J. Med. 6:37, 1935. 5. Weidman, F. D., and Freeman, W.: Xanthoma Tuberosum: 2 Necropsies Disclosing Lesions of the Central Nervous System and Other Tissues , Arch. Dermat. & Syph. 9:149 ( (Feb.) ) 1924. 6. Thannhauser, S. J.: (a) Lipidoses: Diseases of the Cellular Lipid Metabolism , in Christian, H. A.: Oxford Loose Leaf Medicine, New York, Oxford University Press, 1940, Vol. 4, pt. (2) , Chap. 7-A , p. 136 7. Thannhauserpt. (2) , Chap. 7-A Lipidoses: Diseases of the Cellular Lipid Metabolism 19404, p. 137 8. Thannhauserpt. (2) , Chap. 7-A Lipidoses: Diseases of the Cellular Lipid Metabolism 19404, p. 149. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

XANTHOMA DISSEMINATUM: An Unusual Form with Extension of Xanthomatous Changes into Muscle

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1952.01530200092013
Publisher site
See Article on Publisher Site

Abstract

Abstract XANTHOMA disseminatum is an entity that is infrequently encountered. It represents a systemic disorder involving the reticuloendothelial system, particularly the reticulum cells and the histiocytes. It differs in the main from xanthoma tuberosum in that the blood serum cholesterol is normal or low1 and the lesions are more commonly found on the flexural surfaces of the skin. In addition to skin involvement, many other organs and tissues have been found with xanthomatous changes. Lesions have been demonstrated on the mucosal surface of the mouth, epiglottis, and larynx, on the cornea and sclera,2 in the pleura, lungs, pituitary gland, and the tuber cinereum,3 in bones, spinal cord, lymph glands, and spleen,4 in the brain,5 in the liver,6 and on the serous surfaces of the pericardium and peritoneum, the walls of the esophagus, stomach, and intestinal mucosa, as well as in glands (thymus, pancreas, and References 1. Thannhauser, S. J., and Magendantz, H.: The Different Clinical Groups of Xanthomatous Diseases: A Clinical Physiological Study of 22 Cases , Ann. Int. Med. 11:1662, 1938.Crossref 2. Pusey, W. A., and Johnstone, O. P.: A Case of Xanthoma Diabeticorum and Lipoma Multiplex, and a Case of Xanthoma Approaching the Diabetic Type with Diabetes Insipidus , J. Cutan. Dis. 26:552, 1908. 3. Turner, A. L.; Davidson, J., and White, A. C.: Xanthomatosis: Some Aspects of Its Blood Chemistry and Pathology , Edinburgh M. J. 32:153, 1925. 4. Horsfall, F. L., Jr., and Smith, W. R.: Schüller-Christian Syndrome: Lipoid Granulomatosis: Defects in the Bones, Exophthalmos and Diabetes Insipidus , Quart. J. Med. 6:37, 1935. 5. Weidman, F. D., and Freeman, W.: Xanthoma Tuberosum: 2 Necropsies Disclosing Lesions of the Central Nervous System and Other Tissues , Arch. Dermat. & Syph. 9:149 ( (Feb.) ) 1924. 6. Thannhauser, S. J.: (a) Lipidoses: Diseases of the Cellular Lipid Metabolism , in Christian, H. A.: Oxford Loose Leaf Medicine, New York, Oxford University Press, 1940, Vol. 4, pt. (2) , Chap. 7-A , p. 136 7. Thannhauserpt. (2) , Chap. 7-A Lipidoses: Diseases of the Cellular Lipid Metabolism 19404, p. 137 8. Thannhauserpt. (2) , Chap. 7-A Lipidoses: Diseases of the Cellular Lipid Metabolism 19404, p. 149.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Jan 1, 1952

References