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Wilson's Disease With Aseptic Meningitis and Penicillamine-Related Cheilosis

Wilson's Disease With Aseptic Meningitis and Penicillamine-Related Cheilosis Abstract THIS report presents a case of Wilson's disease (hepatolenticular degeneration) with two unusual occurrences. The first was a syndrome of recurrent aseptic meningitis representing the initial evidence of a neurological disorder. The second was cheilosis and gingivostomatitis related to penicillamine therapy. Report of a Case A 19-year-old boy was admitted to Metropolitan Hospital in July 1965. In May of that year he had a sudden massive hematemesis. No demonstrable lesion was found on the barium meal roentgenogram, but a deficiency of clotting factors II, V, VII, IX, and X was noted in the blood. Medical history included glomerulonephritis and an anaphylactic penicillin reaction. There was no family history of liver or neurological disease and no previous history of jaundice, alcoholism, or ingestion of hepatotoxins.Physical findings were gynecomastia, splenomegaly, a small liver, and spider nevi. Significant laboratory results were as follows: serum protein, 7 gm/100 cc with 3.7 gm albumin References 1. Scheinberg, I.H., and Sternlieb, I.: Wilson's Disease , Ann Rev Med 16:119-134, 1965.Crossref 2. Wilson, S.A.K.: Progressive Lenticular Degeneration: A Familial Disease Associated With Cirrhosis of the Liver , Brain 34:295-509, 1912.Crossref 3. Richter, R.: The Pallidal Component in Hepato-Lenticular Degeneration , J Neuropath Exp Neurol 7:1-18, 1948.Crossref 4. Hertz, E., and Drew, A.L.: Hepatolenticular Degeneration: Analysis of Dyskinetic Phenomena; Relationship of Degree of Hepatic Damage to Course of the Disease; Nervous Disorders in Disease of the Liver , Arch Neurol Psychiat 63:843-874, 1950.Crossref 5. Jaffe, I.A.; Altman, K.; and Merryman, P.: The Antipyridoxine Effect of Penicillamine in Man J Clin Invest 43:1869-1873, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Wilson's Disease With Aseptic Meningitis and Penicillamine-Related Cheilosis

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00300030116024
Publisher site
See Article on Publisher Site

Abstract

Abstract THIS report presents a case of Wilson's disease (hepatolenticular degeneration) with two unusual occurrences. The first was a syndrome of recurrent aseptic meningitis representing the initial evidence of a neurological disorder. The second was cheilosis and gingivostomatitis related to penicillamine therapy. Report of a Case A 19-year-old boy was admitted to Metropolitan Hospital in July 1965. In May of that year he had a sudden massive hematemesis. No demonstrable lesion was found on the barium meal roentgenogram, but a deficiency of clotting factors II, V, VII, IX, and X was noted in the blood. Medical history included glomerulonephritis and an anaphylactic penicillin reaction. There was no family history of liver or neurological disease and no previous history of jaundice, alcoholism, or ingestion of hepatotoxins.Physical findings were gynecomastia, splenomegaly, a small liver, and spider nevi. Significant laboratory results were as follows: serum protein, 7 gm/100 cc with 3.7 gm albumin References 1. Scheinberg, I.H., and Sternlieb, I.: Wilson's Disease , Ann Rev Med 16:119-134, 1965.Crossref 2. Wilson, S.A.K.: Progressive Lenticular Degeneration: A Familial Disease Associated With Cirrhosis of the Liver , Brain 34:295-509, 1912.Crossref 3. Richter, R.: The Pallidal Component in Hepato-Lenticular Degeneration , J Neuropath Exp Neurol 7:1-18, 1948.Crossref 4. Hertz, E., and Drew, A.L.: Hepatolenticular Degeneration: Analysis of Dyskinetic Phenomena; Relationship of Degree of Hepatic Damage to Course of the Disease; Nervous Disorders in Disease of the Liver , Arch Neurol Psychiat 63:843-874, 1950.Crossref 5. Jaffe, I.A.; Altman, K.; and Merryman, P.: The Antipyridoxine Effect of Penicillamine in Man J Clin Invest 43:1869-1873, 1964.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1967

References