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Wider Meaning for Lactate Dehydrogenase in Acquired Immunodeficiency Syndrome

Wider Meaning for Lactate Dehydrogenase in Acquired Immunodeficiency Syndrome Abstract As recently discussed by several authors, increased concentrations of lactate dehydrogenase (LDH) in patients with the acquired immunodeficiency syndrome (AIDS) and with altered chest roentgenograms strongly suggest a Pneumocystis carinii pneumonia.1-4 A similar analysis was considered for Mycobacterium tuberculosis, a very frequent pathogen in Mexican patients with AIDS. Specimens from 40 patients with AIDS were studied in a search for both mycobacteria and P carinii in sputum and/or bronchial washings with serum LDH determinations. Overall, the average LDH level was 508.65 IU. Eight patients (20%) were mycobacteria-positive, with an LDH medium of 525.20 IU, whereas 17 patients (42.5%) proved positive for P carinii with an LDH medium of 496.82 IU. Mycobacteria-negative patients had an LDH medium of 504.5 IU, while P carinii—negative patients had LDH media of 517.3 IU. Kruskal-Wallis analysis yielded a significant two-tailed test result (P=.05363), and a Mann-Whitney U analysis was rendered not significant. References 1. Pol Boudes MD. Practical utility of lactate dehydrogenase in the diagnosis of human immunodeficiency virus related Pneumocystis carinii pneumonia . Arch Intern Med . 1991;151:198.Crossref 2. Kawaga FT, Kirsch CM, Yenokida GC, Levine ML. Serum lactate dehydrogenase activity in patients with AIDS and Pneumocystis carinii pneumonia . Chest . 1988;94:1031-1033.Crossref 3. Zaman MK, White DA. Serum lactate dehydrogenase level and Pneumocystis carinii pneumonia infection: diagnostic and prognostic significance . Am Rev Respir Dis . 1988;137:796-800.Crossref 4. O'Brien MD. In search of shortcuts: definitive and indirect tests in the diagnosis of Pneumocystis carinii pneumonia in AIDS . Am Rev Respir Dis . 1989; 139:1324-1327.Crossref 5. Silverman BA, Rubistein A. Serum lactate dehydrogenase levels in adults and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex: possible indicator of B cell lymphoproliferation and disease activity . Am J Med . 1985;78:728-736.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Wider Meaning for Lactate Dehydrogenase in Acquired Immunodeficiency Syndrome

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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1994.00420110144020
Publisher site
See Article on Publisher Site

Abstract

Abstract As recently discussed by several authors, increased concentrations of lactate dehydrogenase (LDH) in patients with the acquired immunodeficiency syndrome (AIDS) and with altered chest roentgenograms strongly suggest a Pneumocystis carinii pneumonia.1-4 A similar analysis was considered for Mycobacterium tuberculosis, a very frequent pathogen in Mexican patients with AIDS. Specimens from 40 patients with AIDS were studied in a search for both mycobacteria and P carinii in sputum and/or bronchial washings with serum LDH determinations. Overall, the average LDH level was 508.65 IU. Eight patients (20%) were mycobacteria-positive, with an LDH medium of 525.20 IU, whereas 17 patients (42.5%) proved positive for P carinii with an LDH medium of 496.82 IU. Mycobacteria-negative patients had an LDH medium of 504.5 IU, while P carinii—negative patients had LDH media of 517.3 IU. Kruskal-Wallis analysis yielded a significant two-tailed test result (P=.05363), and a Mann-Whitney U analysis was rendered not significant. References 1. Pol Boudes MD. Practical utility of lactate dehydrogenase in the diagnosis of human immunodeficiency virus related Pneumocystis carinii pneumonia . Arch Intern Med . 1991;151:198.Crossref 2. Kawaga FT, Kirsch CM, Yenokida GC, Levine ML. Serum lactate dehydrogenase activity in patients with AIDS and Pneumocystis carinii pneumonia . Chest . 1988;94:1031-1033.Crossref 3. Zaman MK, White DA. Serum lactate dehydrogenase level and Pneumocystis carinii pneumonia infection: diagnostic and prognostic significance . Am Rev Respir Dis . 1988;137:796-800.Crossref 4. O'Brien MD. In search of shortcuts: definitive and indirect tests in the diagnosis of Pneumocystis carinii pneumonia in AIDS . Am Rev Respir Dis . 1989; 139:1324-1327.Crossref 5. Silverman BA, Rubistein A. Serum lactate dehydrogenase levels in adults and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex: possible indicator of B cell lymphoproliferation and disease activity . Am J Med . 1985;78:728-736.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 13, 1994

References