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Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder

Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder Key PointsQuestionDoes whole-body hyperthermia have an antidepressant effect not accounted for by placebo factors alone and, if so, how long does this effect last following a single treatment? FindingsIn this randomized clinical trial, when compared with a sham-control condition, a single session of whole-body hyperthermia produced a significant antidepressant effect apparent within a week of treatment that persisted for 6 weeks after treatment. MeaningWhole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Additional studies are required to evaluate whether different levels of heat exposure or repeated treatments might increase the intervention’s antidepressant signal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2016.1031
pmid
27172277
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes whole-body hyperthermia have an antidepressant effect not accounted for by placebo factors alone and, if so, how long does this effect last following a single treatment? FindingsIn this randomized clinical trial, when compared with a sham-control condition, a single session of whole-body hyperthermia produced a significant antidepressant effect apparent within a week of treatment that persisted for 6 weeks after treatment. MeaningWhole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Additional studies are required to evaluate whether different levels of heat exposure or repeated treatments might increase the intervention’s antidepressant signal.

Journal

JAMA PsychiatryAmerican Medical Association

Published: Aug 1, 2016

References