Key PointsQuestionDoes whole-body hyperthermia have an antidepressant effect not accounted for by placebo factors alone and, if so, how long does this effect last following a single treatment? FindingsIn this randomized clinical trial, when compared with a sham-control condition, a single session of whole-body hyperthermia produced a significant antidepressant effect apparent within a week of treatment that persisted for 6 weeks after treatment. MeaningWhole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Additional studies are required to evaluate whether different levels of heat exposure or repeated treatments might increase the intervention’s antidepressant signal.
JAMA Psychiatry – American Medical Association
Published: Aug 1, 2016